Analysis of fibroblasts at various time points up to 36 hours after serum stimulation. The fibroblast serum response represents a wound healing program; cancer progression is likened to wound healing gone awry. Results provide insight into the significance of the wound healing process in cancer.
Chang HY, Sneddon JB, Alizadeh AA, Sood R et al. Gene expression signature of fibroblast serum response predicts human cancer progression: similarities between tumors and wounds. PLoS Biol 2004 Feb;2(2):E7. PMID: 14737219
