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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1979 1
1981 1
1984 1
1985 1
1986 1
1987 2
1988 5
1989 2
1990 5
1991 8
1992 5
1993 6
1994 8
1995 5
1996 10
1997 8
1998 9
1999 10
2000 12
2001 11
2002 16
2003 19
2004 16
2005 16
2006 20
2007 18
2008 18
2009 18
2010 15
2011 23
2012 17
2013 27
2014 25
2015 27
2016 22
2017 15
2018 20
2019 18
2020 26
2021 22
2022 20
2023 16
2024 4

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501 results

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Page 1
Advances in the diagnosis and treatment of sickle cell disease.
Brandow AM, Liem RI. Brandow AM, et al. J Hematol Oncol. 2022 Mar 3;15(1):20. doi: 10.1186/s13045-022-01237-z. J Hematol Oncol. 2022. PMID: 35241123 Free PMC article. Review.
In this review, we discuss advances in the diagnosis and management of four major complications: acute and chronic pain, cardiopulmonary disease, central nervous system disease and kidney disease. We also discuss advances in disease-modifying and curative therapeutic optio …
In this review, we discuss advances in the diagnosis and management of four major complications: acute and chronic pain, cardiopulmonary dis …
The Immunobiology and Pathogenesis of Celiac Disease.
Iversen R, Sollid LM. Iversen R, et al. Annu Rev Pathol. 2023 Jan 24;18:47-70. doi: 10.1146/annurev-pathmechdis-031521-032634. Epub 2022 Sep 6. Annu Rev Pathol. 2023. PMID: 36067801 Free article. Review.
Among human leukocyte antigen (HLA)-associated disorders, celiac disease has an immunopathogenesis that is particularly well understood. ...We now have mechanistic insights into how the disease-predisposing HLA-DQ molecules, via presentation of posttranslationally …
Among human leukocyte antigen (HLA)-associated disorders, celiac disease has an immunopathogenesis that is particularly well understo …
An overview of autoantibodies in rheumatoid arthritis.
van Delft MAM, Huizinga TWJ. van Delft MAM, et al. J Autoimmun. 2020 Jun;110:102392. doi: 10.1016/j.jaut.2019.102392. Epub 2020 Jan 3. J Autoimmun. 2020. PMID: 31911013 Free article. Review.
The presence of autoantibodies is a hallmark for the disease, among these are rheumatoid factor and antibodies against post-translational modified proteins like citrullination (ACPA) and carbamylation (anti-CarP antibodies). ...Both subsets can be associated with genetic a …
The presence of autoantibodies is a hallmark for the disease, among these are rheumatoid factor and antibodies against post-translational …
Prophylaxis and management of graft versus host disease after stem-cell transplantation for haematological malignancies: updated consensus recommendations of the European Society for Blood and Marrow Transplantation.
Penack O, Marchetti M, Ruutu T, Aljurf M, Bacigalupo A, Bonifazi F, Ciceri F, Cornelissen J, Malladi R, Duarte RF, Giebel S, Greinix H, Holler E, Lawitschka A, Mielke S, Mohty M, Arat M, Nagler A, Passweg J, Schoemans H, Socié G, Solano C, Vrhovac R, Zeiser R, Kröger N, Basak GW. Penack O, et al. Lancet Haematol. 2020 Feb;7(2):e157-e167. doi: 10.1016/S2352-3026(19)30256-X. Lancet Haematol. 2020. PMID: 32004485 Review.
In 2014, to standardise treatment approaches the European Society of Blood and Marrow Transplantation published recommendations on the management of GVHD in the setting of HLA-identical sibling or unrelated donor transplantation in adult patients with haematological malign …
In 2014, to standardise treatment approaches the European Society of Blood and Marrow Transplantation published recommendations on the manag …
The heterogeneous pathogenesis of type 1 diabetes mellitus.
Ilonen J, Lempainen J, Veijola R. Ilonen J, et al. Nat Rev Endocrinol. 2019 Nov;15(11):635-650. doi: 10.1038/s41574-019-0254-y. Epub 2019 Sep 18. Nat Rev Endocrinol. 2019. PMID: 31534209 Review.
Genetic risk is defined by the presence of particular allele combinations, which in the major susceptibility locus (the HLA region) affect T cell recognition and tolerance to foreign and autologous molecules. Multiple other loci also regulate and affect features of specifi …
Genetic risk is defined by the presence of particular allele combinations, which in the major susceptibility locus (the HLA region) a …
NK cells and ILCs in tumor immunotherapy.
Sivori S, Pende D, Quatrini L, Pietra G, Della Chiesa M, Vacca P, Tumino N, Moretta F, Mingari MC, Locatelli F, Moretta L. Sivori S, et al. Mol Aspects Med. 2021 Aug;80:100870. doi: 10.1016/j.mam.2020.100870. Epub 2020 Aug 13. Mol Aspects Med. 2021. PMID: 32800530 Free article. Review.
This limitation may be overcome by the use of IL-15, particularly of modified IL-15 molecules to improve its half-life and optimize the biological effects. ...This effect may be predominant and crucial in tumors that have lost HLA cl-I expression, thus resulting "in …
This limitation may be overcome by the use of IL-15, particularly of modified IL-15 molecules to improve its half-life and optimize t …
Origins and immunopathogenesis of autoimmune central nervous system disorders.
Ramanathan S, Brilot F, Irani SR, Dale RC. Ramanathan S, et al. Nat Rev Neurol. 2023 Mar;19(3):172-190. doi: 10.1038/s41582-023-00776-4. Epub 2023 Feb 14. Nat Rev Neurol. 2023. PMID: 36788293 Review.
In this article, we review the key pathogenic mechanisms underlying the development of CNS autoimmunity. First, we review non-modifiable risk factors, such as age, sex and ethnicity, as well as genetic factors such as monogenic variants, common variants in vulnerability ge …
In this article, we review the key pathogenic mechanisms underlying the development of CNS autoimmunity. First, we review non-modifiable …
Interactions between genetic, lifestyle and environmental risk factors for multiple sclerosis.
Olsson T, Barcellos LF, Alfredsson L. Olsson T, et al. Nat Rev Neurol. 2017 Jan;13(1):25-36. doi: 10.1038/nrneurol.2016.187. Epub 2016 Dec 9. Nat Rev Neurol. 2017. PMID: 27934854 Review.
Certain factors - smoking, EBV infection and obesity - interact with HLA risk genes, pointing at a pathogenetic pathway involving adaptive immunity. ...Unlike genetic risk factors, many environmental and lifestyle factors can be modified, with potential for preventi …
Certain factors - smoking, EBV infection and obesity - interact with HLA risk genes, pointing at a pathogenetic pathway involving ada …
Exagamglogene Autotemcel: First Approval.
Hoy SM. Hoy SM. Mol Diagn Ther. 2024 Mar;28(2):133-139. doi: 10.1007/s40291-024-00696-z. Epub 2024 Jan 17. Mol Diagn Ther. 2024. PMID: 38228954 Review.
Exagamglogene autotemcel (Casgevy) is a genetically modified autologous CD34(+) cell enriched population. It contains human haematopoietic stem and progenitor cells edited ex vivo by CRISPR/Cas9 (a DNA double strand break-inducing nuclease system) to differentiate into ery …
Exagamglogene autotemcel (Casgevy) is a genetically modified autologous CD34(+) cell enriched population. It contains human haematopo …
A Path Toward Precision Medicine for Neuroinflammatory Mechanisms in Alzheimer's Disease.
Hampel H, Caraci F, Cuello AC, Caruso G, Nisticò R, Corbo M, Baldacci F, Toschi N, Garaci F, Chiesa PA, Verdooner SR, Akman-Anderson L, Hernández F, Ávila J, Emanuele E, Valenzuela PL, Lucía A, Watling M, Imbimbo BP, Vergallo A, Lista S. Hampel H, et al. Front Immunol. 2020 Mar 31;11:456. doi: 10.3389/fimmu.2020.00456. eCollection 2020. Front Immunol. 2020. PMID: 32296418 Free PMC article. Review.
Large-scale genome-wide association studies point out several genetic variants-TREM2, CD33, PILRA, CR1, MS4A, CLU, ABCA7, EPHA1, and HLA-DRB5-HLA-DRB1-potentially linked to neuroinflammation. Most of these genes are involved in proinflammatory intracellular signalin …
Large-scale genome-wide association studies point out several genetic variants-TREM2, CD33, PILRA, CR1, MS4A, CLU, ABCA7, EPHA1, and HLA …
501 results