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Page 1
Dissecting the Genetics of Osteoporosis using Systems Approaches.
Al-Barghouthi BM, Farber CR. Al-Barghouthi BM, et al. Trends Genet. 2019 Jan;35(1):55-67. doi: 10.1016/j.tig.2018.10.004. Epub 2018 Nov 20. Trends Genet. 2019. PMID: 30470485 Free PMC article. Review.
Osteoporosis is a condition characterized by low bone mineral density (BMD) and an increased risk of fracture. Traits contributing to osteoporotic fracture are highly heritable, indicating that a comprehensive understanding of bone requires a thorough …
Osteoporosis is a condition characterized by low bone mineral density (BMD) and an increased risk of fracture. Traits c …
Role of genetics in osteoporosis.
Recker RR, Deng HW. Recker RR, et al. Endocrine. 2002 Feb;17(1):55-66. doi: 10.1385/ENDO:17:1:55. Endocrine. 2002. PMID: 12014706 Review.
It is a serious health problem, especially in elderly women. Bone mineral density (BMD) has been employed most commonly as the index for defining and studying osteoporosis. ...Finally, we review and discuss the current status for mapping and identification of …
It is a serious health problem, especially in elderly women. Bone mineral density (BMD) has been employed most commonly …
Genetic regulation of bone mass: from bone density to bone strength.
Langman CB. Langman CB. Pediatr Nephrol. 2005 Mar;20(3):352-5. doi: 10.1007/s00467-004-1687-6. Epub 2005 Jan 5. Pediatr Nephrol. 2005. PMID: 15633054 Review.
These include (1) the finding of quantitative trait loci for bone density, (2) the finding that specific mutations in genes that are important in the development of osteoblast or osteoclast lineages alter bone density, and ( …
These include (1) the finding of quantitative trait loci for bone density, (2) the finding that sp …
A close examination of genes within quantitative trait loci of bone mineral density in whole mouse genome.
Xiong Q, Han C, Beamer WG, Gu W. Xiong Q, et al. Crit Rev Eukaryot Gene Expr. 2008;18(4):323-43. doi: 10.1615/critreveukargeneexpr.v18.i4.20. Crit Rev Eukaryot Gene Expr. 2008. PMID: 18652562 Review.
Bone mineral density (BMD) is one of the strongest determinants of osteoporotic fracture risk. Over the last decade, a large number of quantitative trait loci (QTL) that regulate BMD have been identified using the mouse model. ...
Bone mineral density (BMD) is one of the strongest determinants of osteoporotic fracture risk. Over the last decade, a …
Genetic control of susceptibility to osteoporosis.
Ralston SH. Ralston SH. J Clin Endocrinol Metab. 2002 Jun;87(6):2460-6. doi: 10.1210/jcem.87.6.8621. J Clin Endocrinol Metab. 2002. PMID: 12050200 Review.
Twin studies have shown that genetic factors play an important role in regulating bone mineral density (BMD), ultrasound properties of bone, skeletal geometry, and bone turnover as well as contributing to the pathogenesis of osteoporotic fractur …
Twin studies have shown that genetic factors play an important role in regulating bone mineral density (BMD), ultrasoun …
Gene variants for osteoporosis and their pleiotropic effects in aging.
Ferrari SL, Rizzoli R. Ferrari SL, et al. Mol Aspects Med. 2005 Jun;26(3):145-67. doi: 10.1016/j.mam.2005.01.002. Mol Aspects Med. 2005. PMID: 15811432 Review.
Numerous genetic, hormonal, nutritional and life-style factors contribute to the acquisition and maintenance of bone mass. Among them, genetic variations explain as much as 70% of the variance for bone mineral density (BMD) in the population. Dozens of …
Numerous genetic, hormonal, nutritional and life-style factors contribute to the acquisition and maintenance of bone mass. Among them …
Genetic determinants of bone mass.
Audí L, García-Ramírez M, Carrascosa A. Audí L, et al. Horm Res. 1999;51(3):105-23. doi: 10.1159/000023343. Horm Res. 1999. PMID: 10461016 Review.
The first to be described was the vitamin D receptor gene (VDR), initially claimed to contribute to almost 75% of the genetic variation in bone mineral density (BMD) in twin and general population studies. ...Again, the molecular basis for the contribution of …
The first to be described was the vitamin D receptor gene (VDR), initially claimed to contribute to almost 75% of the genetic variation in …
Defining the genetics of osteoporosis: using the mouse to understand man.
Rosen CJ, Beamer WG, Donahue LR. Rosen CJ, et al. Osteoporos Int. 2001;12(10):803-10. doi: 10.1007/s001980170030. Osteoporos Int. 2001. PMID: 11716182 Review.
Very low bone mineral density (BMD) is now considered as diagnostic of osteoporosis. ...Progress in this area with these strains has been rapid, and a summary of several quantitative trait loci (QTLs) is provided. The future of the mouse …
Very low bone mineral density (BMD) is now considered as diagnostic of osteoporosis. ...Progress in this area with thes …
Recent advances in the genetics of osteoporosis.
Williams FM, Spector TD. Williams FM, et al. J Musculoskelet Neuronal Interact. 2006 Jan-Mar;6(1):27-35. J Musculoskelet Neuronal Interact. 2006. PMID: 16675887 Free article. Review.
It has been known for over 20 years that osteoporosis is highly influenced by genetic factors. Bone mineral density (BMD) has also been shown to be highly heritable. ...These include linkage studies in man and experimental animals as well as candidate gene st …
It has been known for over 20 years that osteoporosis is highly influenced by genetic factors. Bone mineral density (BM …
The insulin-like growth factor-I gene and osteoporosis: a critical appraisal.
Niu T, Rosen CJ. Niu T, et al. Gene. 2005 Nov 21;361:38-56. doi: 10.1016/j.gene.2005.07.016. Epub 2005 Sep 22. Gene. 2005. PMID: 16183214 Review.
Osteoporosis, a disorder of skeletal fragility, is common in the elderly, and its prevalence is increasing as more individuals with low bone mineral density (BMD), the strongest predictor of fracture risk, are detected. ...Recently, polymorphisms upstream of …
Osteoporosis, a disorder of skeletal fragility, is common in the elderly, and its prevalence is increasing as more individuals with low b …
12 results