Making a new turn in matrix metalloprotease inhibition

Zelda R Wasserman

doi:10.1016/j.chembiol.2005.01.008

Making a new turn in matrix metalloprotease inhibition

Chem Biol. 2005 Feb;12(2):143-4. doi: 10.1016/j.chembiol.2005.01.008.

Author

Zelda R Wasserman¹

Affiliation

¹ Incyte Corporation, Experimental Station, Route 141 and Henry Clay Road, Wilmington, Delaware 19880, USA

PMID: 15734640
DOI: 10.1016/j.chembiol.2005.01.008

Abstract

The paradigm for matrix metalloprotease inhibition combines active site tailoring and catalytic zinc ligation. But, selectivity has been difficult. Now, Engel et al. present novel compounds, completely selective for MMP-13, with a unique binding mode.

Publication types

Comment
Review

MeSH terms

Catalysis
Catalytic Domain
Enzyme Inhibitors
Matrix Metalloproteinase Inhibitors*
Matrix Metalloproteinases / chemistry*
Protein Structure, Secondary

Substances

Enzyme Inhibitors
Matrix Metalloproteinase Inhibitors
Matrix Metalloproteinases