PubMed (RefSeq) for id: 2462597976

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38483988,38279565,38268032,38244948,38055341,38032106,38014700,38008853,37866880,37681873,37658431,37408248,37393311,37249289,37247277,37202390,37047300,36991467,36989847,36934104,36856422,36828627,36758484,36746261,36691031,36672454,36602428,36591289,36481094,36473865,36448053,36427396,36395886,36322817,36278408,36271031,36240645,36159747,36104103,36002342,35880246,35844805,35840806,35821235,35768390,35508987,35438057,35395208,35391558,35359405,35348966,35346215,35301297,35280682,35273678,35225231,35194762,35182481,35140242,35129045,35094292,35089787,35058228,35013218,34953047,34869326,34817806,34755101,34741373,34717891,34671019,34591642,34487730,34372947,34369622,34347919,34335983,34298040,34288252,34278448,34217244,34133714,34102342,34046815,33972717,33962073,33961781,33886022,33872388,33824312,33824269,33821962,33677796,33676554,33676386,33658012,33637726,33504946,33494392,33471866,33291075,33288957,33205306,33188146,33147048,33086033,33078455,32931083,32915667,32907612,32792479,32791990,32776544,32707033,32694731,32588541,32572904,32457290,32444799,32437091,32433022,32402537,32396860,32380038,32371478,32369227,32353058,32352219,32350066,32345600,32329846,32308754,32301540,32284542,32276600,32248654,32239181,32124957,32113998,32094308,32086376,32081857,32051583,32049388,32047362,32041737,32032908,32024555,32021252,31940492,31868589,31843895,31772025,31741433,31740732,31679460,31638140,31612394,31569395,31519156,31450901,31409638,31371703,31351478,31346036,31337255,31289136,31285543,31281471,31244938,31210753,31202256,31186535,31161818,31152129,31119177,31064356,30981757,30922330,30898011,30883339,30865892,30854619,30854564,30830867,30789902,30783098,30783083,30742097,30728155,30722038,30606768,30601691,30535501,30510140,30365154,30343112,30302867,30284149,30250038,30177679,30098297,30094882,30086763,30044990,29964355,29891922,29735700,29720189,29701752,29695787,29665239,29638162,29633504,29534580,29507755,29499133,29475832,29427543,29408378,29384474,29355657,29346117,29324317,29225075,29200162,29198712,29150959,29149593,29135520,29103612,29097832,29074464,29072128,28920929,28903484,28850619,28829765,28806398,28772241,28765935,28763841,28760857,28727686,28722108,28716020,28699179,28656290,28619760,28614300,28581525,28522751,28514442,28498285,28464881,28459460,28424412,28423622,28422719,28407575,28287082,28242758,28209614,28202514,28184929,28069547,28069035,28036276,28007894,28000899,28000896,27880917,27852700,27837025,27806347,27795300,27773673,27764699,27751849,27704356,27625374,27593557,27579997,27566146,27486687,27485116,27470268,27458189,27423313,27409838,27350307,27306418,27247421,27244218,27238018,27232758,27229929,27152455,26983463,26976582,26954701,26912724,26898828,26774344,26774286,26759235,26602384,26540345,26482194,26474281,26464659,26461473,26458995,26354767,26341754,26324296,26323375,26306035,26269414,26206584,26173098,26163148,26108681,26097998,26091241,26087183,26033182,25955618,25944166,25918246,25897075,25893295,25888377,25885523,25860929,25855785,25775507,25753158,25749036,25720964,25716680,25670854,25669969,25640309,25623537,25622249,25586348,25555218,25515538,25493453,25450649,25445601,25437563,25344755,25314076,25269767,25204433,25159729,25143387,24912918,24912190,24884509,24853181,24838835,24820417,24811168,24793136,24752894,24731221,24727676,24686546,24586741,24424791,24412244,24398687,24377525,24362026,24344117,24298052,24166518,24165483,24113472,24091628,24085301,24053468,24000165,23955342,23954152,23858059,23857984,23823476,23820376,23791182,23776410,23750012,23676439,23670162,23623971,23575666,23558291,23514585,23507969,23453757,23381582,23324394,23322298,23232523,23228967,23219661,23166673,23108047,23095493,23082202,23040356,23022380,22975506,22939624,22923510,22864569,22848434,22814294,22797700,22710716,22708077,22658674,22608923,22576686,22524983,22513362,22426484,22405651,22399798,22388891,22307056,22285861,22270966,22144179,22108521,22017876,21964756,21953459,21873635,21860413,21835957,21820430,21798897,21620836,21597324,21368833,21254166,21220517,21205095,21147854,21145461,21134077,21123947,21122106,21092141,21070969,20970423,20944675,20890303,20861920,20861909,20852628,20848231,20826802,20823234,20815813,20683149,20638938,20622901,20596027,20571051,20558726,20534483,20484041,20448329,20388706,20338046,20332316,20208556,19956254,19847202,19794083,19739118,19692168,19679664,19635999,19625176,19587092,19490893,19423708,19420964,19412162,19366810,19351817,19340001,19245433,19193609,19170196,19126544,19124506,19111882,19109228,19084516,19028597,18938137,18931460,18787170,18784078,18765672,18676680,18660489,18625840,18559665,18541364,18485478,18428053,18414042,18391985,18354482,18198341,18094723,17992009,17909182,17909001,17873522,17646409,17646408,17588203,17558397,17526737,17434132,17320938,17314511,17298674,17274947,17189384,17157259,16938571,16863506,16825193,16818231,16344560,16338364,16210249,16169070,16054087,16023596,15980150,15917200,15611062,15520277,15498494,15489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Results by year

Year	Number of Results
1994	2
1999	1
2001	6
2002	3
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2004	15
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2007	14
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2009	24
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585 results

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Epidermal growth factor receptor (EGFR) is a target of the tumor-suppressor E3 ligase FBXW7.

Boretto M, Geurts MH, Gandhi S, Ma Z, Staliarova N, Celotti M, Lim S, He GW, Millen R, Driehuis E, Begthel H, Smabers L, Roodhart J, van Es J, Wu W, Clevers H. Boretto M, et al. Proc Natl Acad Sci U S A. 2024 Mar 19;121(12):e2309902121. doi: 10.1073/pnas.2309902121. Epub 2024 Mar 14. Proc Natl Acad Sci U S A. 2024. PMID: 38483988 Free PMC article.

ASPM stabilizes the NOTCH intracellular domain 1 and promotes oncogenesis by blocking FBXW7 binding in hepatocellular carcinoma cells.

Chan TS, Cheng LH, Hsu CC, Yang PM, Liao TY, Hsieh HY, Lin PC, HuangFu WC, Chuu CP, Tsai KK. Chan TS, et al. Mol Oncol. 2024 Mar;18(3):562-579. doi: 10.1002/1878-0261.13589. Epub 2024 Jan 26. Mol Oncol. 2024. PMID: 38279565 Free PMC article.

Fbxw7 suppresses carcinogenesis and stemness in triple-negative breast cancer through CHD4 degradation and Wnt/β-catenin pathway inhibition.

Xiao G, Lu W, Yuan J, Liu Z, Wang P, Fan H. Xiao G, et al. J Transl Med. 2024 Jan 24;22(1):99. doi: 10.1186/s12967-024-04897-2. J Transl Med. 2024. PMID: 38268032 Free PMC article.

FBXW7 polymorphism asserts susceptibility to colorectal cancer.

Uroog L, Zeya B, Imtiyaz K, Ahmad Wani R, Moshahid Alam Rizvi M. Uroog L, et al. Gene. 2024 Apr 5;901:148181. doi: 10.1016/j.gene.2024.148181. Epub 2024 Jan 19. Gene. 2024. PMID: 38244948

FBXW7 affects autophagy through MCL1 in oral squamous cell carcinoma.

Sun Y, Nie W, Qiu B, Yang Q, Zhao H. Sun Y, et al. Oral Dis. 2023 Nov;29(8):3259-3267. doi: 10.1111/odi.14325. Epub 2022 Aug 9. Oral Dis. 2023. PMID: 38055341

FBXW7-loss Sensitizes Cells to ATR Inhibition Through Induced Mitotic Catastrophe.

O'Brien S, Ubhi T, Wolf L, Gandhi K, Lin S, Chaudary N, Dhani NC, Milosevic M, Brown GW, Angers S. O'Brien S, et al. Cancer Res Commun. 2023 Dec 21;3(12):2596-2607. doi: 10.1158/2767-9764.CRC-23-0306. Cancer Res Commun. 2023. PMID: 38032106 Free PMC article.

FBXW7 inhibits the progression of ESCC by directly inhibiting the stemness of tumor cells.

Bi Y, Yang Y, Zhang Y, Cheng C, Tang P, Xiao H, Yuan F, Wu W, Yang B. Bi Y, et al. Neoplasma. 2023 Dec;70(6):733-746. doi: 10.4149/neo_2023_230104N8. Epub 2023 Nov 28. Neoplasma. 2023. PMID: 38014700

E3-ubiquitin ligase, FBXW7 regulates mitotic progression by targeting BubR1 for ubiquitin-mediated degradation.

Nair VM, Sabu AS, Hussain A, Kombarakkaran DP, Lakshmi RB, Manna TK. Nair VM, et al. Cell Mol Life Sci. 2023 Nov 26;80(12):374. doi: 10.1007/s00018-023-05019-9. Cell Mol Life Sci. 2023. PMID: 38008853 Free PMC article.

Cancer-associated FBXW7 loss is synthetic lethal with pharmacological targeting of CDC7.

Baxter JS, Brough R, Krastev DB, Song F, Sridhar S, Gulati A, Alexander J, Roumeliotis TI, Kozik Z, Choudhary JS, Haider S, Pettitt SJ, Tutt ANJ, Lord CJ. Baxter JS, et al. Mol Oncol. 2024 Feb;18(2):369-385. doi: 10.1002/1878-0261.13537. Epub 2023 Oct 22. Mol Oncol. 2024. PMID: 37866880 Free PMC article.

The Highs and Lows of FBXW7: New Insights into Substrate Affinity in Disease and Development.

de la Cova CC. de la Cova CC. Cells. 2023 Aug 24;12(17):2141. doi: 10.3390/cells12172141. Cells. 2023. PMID: 37681873 Free PMC article. Review.

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