PubMed (GeneRIF) for id: 51520

Year	Number of Results
2005	1
2007	2
2008	1
2009	2
2010	1
2011	1
2012	2
2014	2
2015	1
2017	2
2019	1
2020	5
2021	3
2022	2
2024	0

1

Identification of LARS as an essential gene for osteosarcoma proliferation through large-Scale CRISPR-Cas9 screening database and experimental verification.

Chen W, Lin Y, Jiang M, Wang Q, Shu Q. Chen W, et al. J Transl Med. 2022 Aug 12;20(1):355. doi: 10.1186/s12967-022-03571-9. J Transl Med. 2022. PMID: 35962451 Free PMC article.

2

O-GlcNAc modification of leucyl-tRNA synthetase 1 integrates leucine and glucose availability to regulate mTORC1 and the metabolic fate of leucine.

Kim K, Yoo HC, Kim BG, Kim S, Sung Y, Yoon I, Yu YC, Park SJ, Kim JH, Myung K, Hwang KY, Kim S, Han JM. Kim K, et al. Nat Commun. 2022 May 25;13(1):2904. doi: 10.1038/s41467-022-30696-8. Nat Commun. 2022. PMID: 35614056 Free PMC article.

3

Leucyl-tRNA synthetase 1 is required for proliferation of TSC-null cells.

Bae JH, Kim JH. Bae JH, et al. Biochem Biophys Res Commun. 2021 Sep 24;571:159-166. doi: 10.1016/j.bbrc.2021.07.080. Epub 2021 Jul 27. Biochem Biophys Res Commun. 2021. PMID: 34325132

4

Infantile Liver Failure Syndrome 1 associated with a novel variant of the LARS1 gene: Clinical, genetic, and functional characterization.

Tabolacci E, Molinario C, Marangi G, Nobile V, Arena V, Mendes MI, Smith DEC, Salomons GS, Tana M, Costa S, Vento G, Genuardi M. Tabolacci E, et al. Clin Genet. 2021 Apr;99(4):601-603. doi: 10.1111/cge.13893. Epub 2020 Dec 13. Clin Genet. 2021. PMID: 33314043 No abstract available.

5

Severe course with lethal hepatocellular injury and skeletal muscular dysgenesis in a neonate with infantile liver failure syndrome type 1 caused by novel LARS1 mutations.

Hirata K, Okamoto N, Ichikawa C, Inoue S, Nozaki M, Banno K, Takenouchi T, Suzuki H, Kosaki K. Hirata K, et al. Am J Med Genet A. 2021 Mar;185(3):866-870. doi: 10.1002/ajmg.a.62012. Epub 2020 Dec 10. Am J Med Genet A. 2021. PMID: 33300650

6

Genotypic diversity and phenotypic spectrum of infantile liver failure syndrome type 1 due to variants in LARS1.

Lenz D, Smith DEC, Crushell E, Husain RA, Salomons GS, Alhaddad B, Bernstein JA, Bianzano A, Biskup S, Brennenstuhl H, Caldari D, Dikow N, Haack TB, Hanson-Kahn A, Harting I, Horn D, Hughes J, Huijberts M, Isidor B, Kathemann S, Kopajtich R, Kotzaeridou U, Küry S, Lainka E, Laugwitz L, Lupski JR, Posey JE, Reynolds C, Rosenfeld JA, Schröter J, Vansenne F, Wagner M, Weiß C, Wolffenbuttel BHR, Wortmann SB, Kölker S, Hoffmann GF, Prokisch H, Mendes MI, Staufner C. Lenz D, et al. Genet Med. 2020 Nov;22(11):1863-1873. doi: 10.1038/s41436-020-0904-4. Epub 2020 Jul 23. Genet Med. 2020. PMID: 32699352 Free article.

7

Molecular basis of the multifaceted functions of human leucyl-tRNA synthetase in protein synthesis and beyond.

Liu RJ, Long T, Li H, Zhao J, Li J, Wang M, Palencia A, Lin J, Cusack S, Wang ED. Liu RJ, et al. Nucleic Acids Res. 2020 May 21;48(9):4946-4959. doi: 10.1093/nar/gkaa189. Nucleic Acids Res. 2020. PMID: 32232361 Free PMC article.

8

Glucose-dependent control of leucine metabolism by leucyl-tRNA synthetase 1.

Yoon I, Nam M, Kim HK, Moon HS, Kim S, Jang J, Song JA, Jeong SJ, Kim SB, Cho S, Kim Y, Lee J, Yang WS, Yoo HC, Kim K, Kim MS, Yang A, Cho K, Park HS, Hwang GS, Hwang KY, Han JM, Kim JH, Kim S. Yoon I, et al. Science. 2020 Jan 10;367(6474):205-210. doi: 10.1126/science.aau2753. Epub 2019 Nov 28. Science. 2020. PMID: 31780625

9

Control of leucine-dependent mTORC1 pathway through chemical intervention of leucyl-tRNA synthetase and RagD interaction.

Kim JH, Lee C, Lee M, Wang H, Kim K, Park SJ, Yoon I, Jang J, Zhao H, Kim HK, Kwon NH, Jeong SJ, Yoo HC, Kim JH, Yang JS, Lee MY, Lee CW, Yun J, Oh SJ, Kang JS, Martinis SA, Hwang KY, Guo M, Han G, Han JM, Kim S. Kim JH, et al. Nat Commun. 2017 Sep 29;8(1):732. doi: 10.1038/s41467-017-00785-0. Nat Commun. 2017. PMID: 28963468 Free PMC article.

10

Leucine-induced localization of Leucyl-tRNA synthetase in lysosome membrane.

Choi H, Son JB, Kang J, Kwon J, Kim JH, Jung M, Kim SK, Kim S, Mun JY. Choi H, et al. Biochem Biophys Res Commun. 2017 Nov 18;493(2):1129-1135. doi: 10.1016/j.bbrc.2017.09.008. Epub 2017 Sep 5. Biochem Biophys Res Commun. 2017. PMID: 28882589

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