PubMed (GeneRIF) for id: 3061

Year	Number of Results
2002	1
2003	1
2004	2
2005	5
2006	2
2007	2
2008	5
2009	6
2010	6
2011	8
2012	4
2013	3
2014	8
2015	9
2016	5
2017	2
2018	5
2019	5
2020	4
2021	3
2023	2
2024	1

1

Orexin-A/OX1R is involved in regulation of autophagy to promote cortisol secretion in adrenocortical cell.

Guo X, Wen J, Gao Q, Zhao Y, Zhao Y, Wang C, Xu N, Shao Y, Chang X. Guo X, et al. Biochim Biophys Acta Mol Basis Dis. 2024 Jan;1870(1):166844. doi: 10.1016/j.bbadis.2023.166844. Epub 2023 Aug 11. Biochim Biophys Acta Mol Basis Dis. 2024. PMID: 37572990 Free article.

2

Internal and external modulation factors of the orexin system (REVIEW).

Maruyama T, Ueta Y. Maruyama T, et al. Peptides. 2023 Jul;165:171009. doi: 10.1016/j.peptides.2023.171009. Epub 2023 Apr 11. Peptides. 2023. PMID: 37054895 Review.

3

Human adipose tissue is a putative direct target of daytime orexin with favorable metabolic effects: A cross-sectional study.

Goldstein N, Tsuneki H, Bhandarkar N, Aimaretti E, Haim Y, Kon K, Sato K, Wada T, Liberty IF, Kirshtein B, Dukhno O, Maixner N, Gepner Y, Sasaoka T, Rudich A. Goldstein N, et al. Obesity (Silver Spring). 2021 Nov;29(11):1857-1867. doi: 10.1002/oby.23262. Epub 2021 Sep 2. Obesity (Silver Spring). 2021. PMID: 34472713

4

Identification and Characterization of Cannabidiol as an OX1R Antagonist by Computational and In Vitro Functional Validation.

Vitale RM, Iannotti FA, Schiano Moriello A, Tunisi L, Piscitelli F, Savopoulos R, Cristino L, De Petrocellis L, Amodeo P, Gray R, Di Marzo V. Vitale RM, et al. Biomolecules. 2021 Aug 1;11(8):1134. doi: 10.3390/biom11081134. Biomolecules. 2021. PMID: 34439801 Free PMC article.

5

Orexin-A protects against cerebral ischemia-reperfusion injury by inhibiting excessive autophagy through OX1R-mediated MAPK/ERK/mTOR pathway.

Xu D, Kong T, Zhang S, Cheng B, Chen J, Wang C. Xu D, et al. Cell Signal. 2021 Mar;79:109839. doi: 10.1016/j.cellsig.2020.109839. Epub 2020 Nov 16. Cell Signal. 2021. PMID: 33212156

6

Association of orexin/hypocretin receptor gene (HCRTR1) with reward sensitivity, and interaction with gender.

Pulver A, Kiive E, Kanarik M, Harro J. Pulver A, et al. Brain Res. 2020 Nov 1;1746:147013. doi: 10.1016/j.brainres.2020.147013. Epub 2020 Jul 9. Brain Res. 2020. PMID: 32652147

7

Orexin A associates with inflammation by interacting with OX1R/OX2R receptor and activating prepro-Orexin in cancer tissues of gastric cancer patients.

Hu S, Niu J, Zhang R, Li X, Luo M, Sang T, Guo J, Liu J, Ding X, Li X, Ma Y, Gao R. Hu S, et al. Gastroenterol Hepatol. 2020 May;43(5):240-247. doi: 10.1016/j.gastrohep.2019.10.006. Epub 2020 Jan 23. Gastroenterol Hepatol. 2020. PMID: 31983458 English, Spanish.

8

Transmembrane peptide 4 and 5 of APJ are essential for its heterodimerization with OX1R.

Wan L, Xu F, Liu C, Ji B, Zhang R, Wang P, Wu F, Pan Y, Yang C, Wang C, Chen J. Wan L, et al. Biochem Biophys Res Commun. 2020 Jan 8;521(2):408-413. doi: 10.1016/j.bbrc.2019.10.146. Epub 2019 Oct 25. Biochem Biophys Res Commun. 2020. PMID: 31668922

9

Orexin/hypocretin receptor gene (HCRTR1) variation is associated with aggressive behaviour.

Harro J, Laas K, Eensoo D, Kurrikoff T, Sakala K, Vaht M, Parik J, Mäestu J, Veidebaum T. Harro J, et al. Neuropharmacology. 2019 Sep 15;156:107527. doi: 10.1016/j.neuropharm.2019.02.009. Epub 2019 Feb 10. Neuropharmacology. 2019. PMID: 30742846

10

Orexin in the anxiety spectrum: association of a HCRTR1 polymorphism with panic disorder/agoraphobia, CBT treatment response and fear-related intermediate phenotypes.

Gottschalk MG, Richter J, Ziegler C, Schiele MA, Mann J, Geiger MJ, Schartner C, Homola GA, Alpers GW, Büchel C, Fehm L, Fydrich T, Gerlach AL, Gloster AT, Helbig-Lang S, Kalisch R, Kircher T, Lang T, Lonsdorf TB, Pané-Farré CA, Ströhle A, Weber H, Zwanzger P, Arolt V, Romanos M, Wittchen HU, Hamm A, Pauli P, Reif A, Deckert J, Neufang S, Höfler M, Domschke K. Gottschalk MG, et al. Transl Psychiatry. 2019 Feb 4;9(1):75. doi: 10.1038/s41398-019-0415-8. Transl Psychiatry. 2019. PMID: 30718541 Free PMC article.

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