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38254077,38236047,38199567,38138160,38050015,37916628,37747773,37656138,37394642,37096763,36940959,36857986,36655671,36629403,36508454,36437548,36286743,36257936,36217154,36178950,36068210,36037111,35997001,35861192,35838883,35815171,35649041,35597526,35230160,35218180,35123571,34887601,34828364,34782755,34716917,34690927,34570302,34569808,34491040,34481255,34480108,34412629,34302632,34282075,34267337,34256299,34204223,34196110,34120801,34115022,34058179,34042179,33993661,33789449,33743705,33728947,33586456,33420349,33400943,33143137,33137098,33065613,33060488,33043448,33024081,33012655,32918123,32874001,32826605,32805304,32767519,32759992,32733112,32733111,32699276,32682874,32589097,32485484,32469422,32466973,32418524,32394887,32316326,32276921,32219146,32189192,32187157,32047265,32037159,31769341,31710684,31616043,31606278,31559921,31389673,31358955,30943525,30843495,30821899,30814768,30792473,30672837,30670877,30661084,30658716,30646129,30592275,30551694,30542809,30536272,30520769,30513034,30411242,30368994,30357957,30133539,30069923,29980881,29930225,29660517,29555325,29549925,29546421,29524040,29479969,29432309,29390987,29325225,29181698,29073588,28872889,28867064,28777243,28730340,28648122,28626197,28606035,28552654,28525288,28368717,28131599,28087463,27883289,27875318,27797974,27749127,27716659,27698402,27665849,27665326,27463022,27388693,27354764,27335380,27304207,27288795,27282366,27272044,27253829,27249031,27203676,27154635,27109434,27108086,26968424,26902503,26856541,26856397,26839488,26768225,26723569,26660002,26652007,26603528,26551314,26542054,26514968,26510986,26503815,26434912,26406933,26369533,26316040,26310775,26298540,26287939,26252353,26235034,26230381,26211952,26084127,25999696,25989235,25967538,25963137,25943116,25941923,25933954,25868121,25857198,25825958,25823457,25803758,25788121,25743120,25720195,25701109,25609939,25555909,25552922,25521354,25510856,25495408,25495406,25469868,25437930,25381333,25378122,25329392,25329115,25296365,25261563,25245581,25240994,25217496,25141893,25138301,25113522,24987171,24948072,24909950,24905532,24865344,24858822,24798722,24682161,24663076,24660534,24640604,24595968,24584466,24557547,24533713,24510399,24495562,24488700,24449363,24376807,24340040,24338437,24329190,24329187,24318876,24279852,24265353,24265036,24257813,24232670,24211060,24192122,24161632,24156754,24151801,24151800,24125101,24121619,24112176,24107805,24098545,24089073,24088226,24088129,24088126,24033670,23985325,23981149,23922954,23897164,23893861,23876819,23872830,23870808,23855716,23851570,23842856,23831869,23809878,23803265,23781139,23737191,23734807,23733622,23728524,23712329,23700791,23691026,23686417,23664723,23644254,23614566,23609392,23570465,23555934,23552177,23545896,23503455,23471717,23469064,23394389,23357843,23350374,23292115,23289191,23280482,23277250,23258538,23213055,23212934,23207012,23167378,22994728,22986607,22948856,22929407,22913530,22905959,22803153,22777153,22775532,22735900,22733239,22718526,22700965,22688624,22661184,22623266,22623212,22531512,22497725,22459173,22428763,22399238,22398969,22355045,22324840,22308038,22303032,22301406,22281720,22281432,22277677,22245658,22216145,22198443,22180372,22180068,22159753,22141351,22109568,22092298,22039821,21989258,21971440,21958961,21956465,21918425,21913948,21907728,21880792,21861665,21860550,21840870,21835244,21826689,21823108,21821735,21803659,21797939,21787170,21749835,21743374,21728792,21677335,21631295,21605066,21599570,21596874,21589866,21543662,21527579,21518482,21486104,21485696,21456632,21449914,21437611,21433154,21430657,21391885,21321564,21248727,21241245,21173786,21140323,21135868,21108610,21072184,21071160,21063774,20970553,20925579,20881950,20878561,20877302,20877299,20863179,20859244,20857895,20851451,20849243,20846929,20828547,20827267,20814331,20809362,20799519,20731819,20727252,20701904,20700584,20686235,20684753,20679960,20656072,20656020,20643254,20634891,20628863,20602615,20599499,20597905,20590588,20590587,20588073,20574415,20565970,20563569,20547595,20531370,20530222,20520586,20515869,20492431,20489028,20473659,20467479,20461808,20459744,20456744,20454926,20435235,20432045,20430047,20421845,20385997,20375710,20373852,20368706,20364044,20350136,20335142,20332423,20309015,20305604,20297661,20225176,20206139,20205348,20201714,20195825,20185366,20174590,20173083,20147896,20137387,20136364,20133509,20124171,20118554,20081063,20075642,20041956,20031551,20009880,20007670,19997080,19995332,19956635,19954746,19954080,19953095,19947517,19946748,19940985,19937844,19910717,19907421,19902987,19892789,19891553,19887477,19866496,19840783,19833260,19823875,19809024,19797609,19781968,19761369,19738170,19719813,19715474,19710642,19710640,19702490,19694742,19692168,19660006,19656108,19652678,19636337,19625176,19604091,19604084,19604081,19597703,19596663,19593802,19593180,19593168,19593158,19575027,19537956,19527514,19523031,19521114,19474452,19470220,19448135,19444434,19438707,19437119,19429471,19421167,19405050,19395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A consideration of CYP2D6 genetic variations in the Ghanaian population as a potential 'culprit' for the tramadol 'abuse crisis'.

Thomford NE, Abraham SA, Nyarko SB, Biney RP. Thomford NE, et al. BMC Med Genomics. 2024 Jan 22;17(1):28. doi: 10.1186/s12920-023-01773-8. BMC Med Genomics. 2024. PMID: 38254077 Free PMC article.

CYP2D6 Genotyping and Inhibition as Predictors of Adverse Drug Reactions in Depressive Disorders.

Holck A, Asp M, Green H, Westrin Å, Reis M. Holck A, et al. J Clin Psychiatry. 2024 Jan 17;85(1):23m14937. doi: 10.4088/JCP.23m14937. J Clin Psychiatry. 2024. PMID: 38236047

Functional maturation of cytochromes P450 3A4 and 2D6 relies on GAPDH- and Hsp90-Dependent heme allocation.

Islam S, Jayaram DT, Biswas P, Stuehr DJ. Islam S, et al. J Biol Chem. 2024 Feb;300(2):105633. doi: 10.1016/j.jbc.2024.105633. Epub 2024 Jan 8. J Biol Chem. 2024. PMID: 38199567 Free PMC article.

Associations between Selected ADRB1 and CYP2D6 Gene Polymorphisms in Children with Ventricular and Supraventricular Arrhythmias.

Moric-Janiszewska E, Smolik S, Szydłowski L, Kapral M. Moric-Janiszewska E, et al. Medicina (Kaunas). 2023 Nov 21;59(12):2057. doi: 10.3390/medicina59122057. Medicina (Kaunas). 2023. PMID: 38138160 Free PMC article.

Novel Independent Trans- and Cis-Genetic Variants Associated with CYP2D6 Expression and Activity in Human Livers.

Smith D, He B, Shi J, Zhu HJ, Wang X. Smith D, et al. Drug Metab Dispos. 2024 Jan 9;52(2):143-152. doi: 10.1124/dmd.123.001548. Drug Metab Dispos. 2024. PMID: 38050015

Nrf2 Regulates the Expression of CYP2D6 by Inhibiting the Activity of Krüppel-Like Factor 9 (KLF9).

Siswanto FM, Handayani MDN, Firmasyah RD, Oguro A, Imaoka S. Siswanto FM, et al. Curr Drug Metab. 2023;24(9):667-681. doi: 10.2174/0113892002271342231013095255. Curr Drug Metab. 2023. PMID: 37916628

Identification of the effects of pathogenic genetic variations of human CYP2C9 and CYP2D6: an in silico approach.

Avsar O. Avsar O. Nucleosides Nucleotides Nucleic Acids. 2024;43(4):356-376. doi: 10.1080/15257770.2023.2262519. Epub 2023 Sep 25. Nucleosides Nucleotides Nucleic Acids. 2024. PMID: 37747773

Effects of CYP2D6 allelic variants on therapy with tamsulosin in patients with benign prostatic hyperplasia.

Abdullaev SP, Shatokhin MN, Tuchkova SN, Abdullaev SP, Teodorovich OV, Loran OB, Sychev DA. Abdullaev SP, et al. Drug Metab Pers Ther. 2023 Sep 4;38(4):323-330. doi: 10.1515/dmpt-2023-0050. eCollection 2023 Dec 1. Drug Metab Pers Ther. 2023. PMID: 37656138

Decreased Analgesic Effect of Tramadol in Japanese Patients with CYP2D6 Intermediate Metabolizers after Orthopedic Surgery.

Kamiya T, Hira D, Nakajima R, Shinoda K, Motomochi A, Morikochi A, Ikeda Y, Isono T, Akabane M, Ueshima S, Kakumoto M, Imai S, Morita SY, Terada T. Kamiya T, et al. Biol Pharm Bull. 2023;46(7):907-913. doi: 10.1248/bpb.b23-00030. Biol Pharm Bull. 2023. PMID: 37394642 Free article.

Utility of CYP2D6 copy number variants as prognostic biomarker in localized anal squamous cell carcinoma.

Trilla-Fuertes L, Gámez-Pozo A, Nogué M, Busquier I, Arias F, López-Campos F, Fernández-Montes A, Ruiz A, Velázquez C, Martín-Bravo C, Pérez-Ruiz E, Asensio E, Hernández-Yagüe X, Rodrigues A, Ghanem I, López-Vacas R, Hafez A, Arias P, Dapía I, Solís M, Dittmann A, Ramos R, Llorens C, Maurel J, Campos-Barros Á, Fresno Vara JÁ, Feliu J. Trilla-Fuertes L, et al. Cancer. 2023 Aug 15;129(16):2581-2592. doi: 10.1002/cncr.34797. Epub 2023 Apr 25. Cancer. 2023. PMID: 37096763

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