Five SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin (SMARC) genes are dispersed in the human genome

Genomics. 1998 Jul 1;51(1):140-3. doi: 10.1006/geno.1998.5343.

Abstract

The SWI/SNF-related, matrix-associated, actin-dependent regulators of chromatin (SMARC), also called BRG1-associated factors, are components of human SWI/SNF-like chromatin-remodeling protein complexes. We mapped five human SMARC genes toregions on four different human chromosomes, SMARCC1 to 3p23-p21, SMARCC2 to 12q13-q14, SMARCD1 to 12q13-q14, SMARCD2 to 17q23-q24, and SMARCD3 to 7q35-q36. SMARCC1, SMARCC2, and SMARCD1 are assigned to chromosomal regions that are frequently involved in somatic rearrangements in human cancers. SMARCD1 was mapped to the critical region of Allgrove syndrome; however, no mutation was identified in one Allgrove syndrome family studied.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Abnormalities, Multiple / genetics
  • Chromatin / metabolism
  • Chromosomal Proteins, Non-Histone
  • Chromosome Mapping
  • Chromosomes, Human / genetics*
  • Chromosomes, Human, Pair 12 / genetics
  • Chromosomes, Human, Pair 17 / genetics
  • Chromosomes, Human, Pair 3 / genetics
  • Chromosomes, Human, Pair 7 / genetics
  • DNA-Binding Proteins
  • Gene Rearrangement
  • Genetic Markers
  • Genome, Human
  • Humans
  • Neoplasms / genetics
  • Syndrome
  • Transcription Factors / genetics*

Substances

  • Chromatin
  • Chromosomal Proteins, Non-Histone
  • DNA-Binding Proteins
  • Genetic Markers
  • SMARCC1 protein, human
  • SMARCC2 protein, human
  • SMARCD1 protein, human
  • SMARCD2 protein, human
  • SMARCD3 protein, human
  • Transcription Factors

Associated data

  • GENBANK/AF109733