Abstract
The SWI/SNF-related, matrix-associated, actin-dependent regulators of chromatin (SMARC), also called BRG1-associated factors, are components of human SWI/SNF-like chromatin-remodeling protein complexes. We mapped five human SMARC genes toregions on four different human chromosomes, SMARCC1 to 3p23-p21, SMARCC2 to 12q13-q14, SMARCD1 to 12q13-q14, SMARCD2 to 17q23-q24, and SMARCD3 to 7q35-q36. SMARCC1, SMARCC2, and SMARCD1 are assigned to chromosomal regions that are frequently involved in somatic rearrangements in human cancers. SMARCD1 was mapped to the critical region of Allgrove syndrome; however, no mutation was identified in one Allgrove syndrome family studied.
Copyright 1998 Academic Press.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Abnormalities, Multiple / genetics
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Chromatin / metabolism
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Chromosomal Proteins, Non-Histone
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Chromosome Mapping
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Chromosomes, Human / genetics*
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Chromosomes, Human, Pair 12 / genetics
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Chromosomes, Human, Pair 17 / genetics
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Chromosomes, Human, Pair 3 / genetics
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Chromosomes, Human, Pair 7 / genetics
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DNA-Binding Proteins
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Gene Rearrangement
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Genetic Markers
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Genome, Human
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Humans
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Neoplasms / genetics
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Syndrome
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Transcription Factors / genetics*
Substances
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Chromatin
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Chromosomal Proteins, Non-Histone
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DNA-Binding Proteins
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Genetic Markers
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SMARCC1 protein, human
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SMARCC2 protein, human
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SMARCD1 protein, human
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SMARCD2 protein, human
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SMARCD3 protein, human
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Transcription Factors