Localization of the human CXC chemokine subfamily on the long arm of chromosome 4 using radiation hybrids

Genomics. 1998 Jan 1;47(1):136-9. doi: 10.1006/geno.1997.5100.

Abstract

All 12 of the human CXC chemokine genes were physically mapped using gene-specific PCR primers and the GenBridge 4 radiation hybrid panel. Nine genes, PF4, PF4V1, GRO1, GCP2, PPBP, IL8, GRO2, GRO3, and SCYB5, were assigned within a 1.8-cR interval of one another on 4q. Two additional genes, MIG and INP10, map within 0.5 cR of each another and 6 cR distal to the above-mentioned group. The final gene, SDF1, is localized on 10q. Phylogenetic analyses of amino acid sequences revealed that SDF1 is the most divergent member and that the physically separated MIG-INP10 pair constitutes a distinct evolutionary lineage.

MeSH terms

  • Chemokines, CXC / genetics*
  • Chromosome Mapping / methods*
  • Chromosomes, Human, Pair 4*
  • Evolution, Molecular
  • Humans
  • Hybrid Cells / radiation effects
  • Phylogeny
  • Polymerase Chain Reaction

Substances

  • Chemokines, CXC