Lamin A/C gene and a related sequence map to human chromosomes 1q12.1-q23 and 10

Somat Cell Mol Genet. 1993 Mar;19(2):203-8. doi: 10.1007/BF01233534.

Abstract

Lamins A and C are products of alternate splicing of one transcript from a single gene. We have isolated a partial cDNA, cE1-2, whose 800-bp sequence is 99% identical to the 3' untranslated region of the lamin A/C gene. We report here the mapping of this gene and a closely related sequence to human chromosomes 1 and 10, more specifically, to 1q12.1-q23. The localization of cE1-2 hybridizing sequences to two different chromosomes suggests that one of these loci represents an as yet unknown member of the lamin gene family, either a pseudogene or an expressed gene.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • CHO Cells
  • Chromosome Mapping
  • Chromosomes, Human, Pair 1*
  • Chromosomes, Human, Pair 10*
  • Cricetinae
  • Humans
  • Hybrid Cells
  • Lamin Type A
  • Lamins
  • Multigene Family
  • Nuclear Proteins / genetics*

Substances

  • Lamin Type A
  • Lamins
  • Nuclear Proteins