A new member of the cytokine receptor gene family maps on chromosome 21 at less than 35 kb from IFNAR

Genomics. 1993 May;16(2):366-73. doi: 10.1006/geno.1993.1199.

Abstract

A full-length cDNA corresponding to a gene mapping to the D21S58 locus was cloned. The encoded protein, called CRF2-4, was shown to be a typical class II member of the cytokine receptor family. The gene encoding CRF2-4 spans more than 30 kb. Its intron/exon structure was determined and shown to be conserved with all other members of the cytokine receptor family. The physical distance between the CRF2-4 gene and its IFNAR neighbor has been narrowed to less than 35 kb.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Cattle
  • Chromosomes, Human, Pair 21*
  • DNA / genetics
  • Exons
  • Genes*
  • Genetic Linkage
  • Humans
  • Interleukin-10 Receptor beta Subunit
  • Membrane Glycoproteins*
  • Mice
  • Molecular Sequence Data
  • Multigene Family
  • Protein Structure, Secondary
  • Receptors, Cytokine*
  • Receptors, Immunologic / genetics*
  • Receptors, Interferon / genetics
  • Sequence Alignment
  • Sequence Homology, Amino Acid

Substances

  • IL10RB protein, human
  • Interleukin-10 Receptor beta Subunit
  • Membrane Glycoproteins
  • Receptors, Cytokine
  • Receptors, Immunologic
  • Receptors, Interferon
  • DNA

Associated data

  • GENBANK/Z17227