Abstract
A full-length cDNA corresponding to a gene mapping to the D21S58 locus was cloned. The encoded protein, called CRF2-4, was shown to be a typical class II member of the cytokine receptor family. The gene encoding CRF2-4 spans more than 30 kb. Its intron/exon structure was determined and shown to be conserved with all other members of the cytokine receptor family. The physical distance between the CRF2-4 gene and its IFNAR neighbor has been narrowed to less than 35 kb.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Animals
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Base Sequence
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Cattle
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Chromosomes, Human, Pair 21*
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DNA / genetics
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Exons
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Genes*
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Genetic Linkage
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Humans
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Interleukin-10 Receptor beta Subunit
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Membrane Glycoproteins*
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Mice
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Molecular Sequence Data
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Multigene Family
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Protein Structure, Secondary
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Receptors, Cytokine*
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Receptors, Immunologic / genetics*
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Receptors, Interferon / genetics
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Sequence Alignment
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Sequence Homology, Amino Acid
Substances
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IL10RB protein, human
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Interleukin-10 Receptor beta Subunit
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Membrane Glycoproteins
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Receptors, Cytokine
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Receptors, Immunologic
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Receptors, Interferon
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DNA