Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor

Science. 1994 May 13;264(5161):965-8. doi: 10.1126/science.8178155.

Abstract

A cytokine was identified that stimulated the proliferation of T lymphocytes, and a complementary DNA clone encoding this new T cell growth factor was isolated. The cytokine, designated interleukin-15 (IL-15), is produced by a wide variety of cells and tissues and shares many biological properties with IL-2. Monoclonal antibodies to the beta chain of the IL-2 receptor inhibited the biological activity of IL-15, and IL-15 competed for binding with IL-2, indicating that IL-15 uses components of the IL-2 receptor.

Publication types

  • Comparative Study

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Cells, Cultured
  • Cloning, Molecular*
  • Haplorhini
  • Humans
  • Interleukin-15
  • Interleukin-2 / immunology
  • Interleukin-2 / metabolism
  • Interleukin-2 / pharmacology
  • Interleukins / chemistry
  • Interleukins / genetics*
  • Interleukins / metabolism
  • Interleukins / pharmacology
  • Killer Cells, Lymphokine-Activated / immunology
  • Leukocytes, Mononuclear / immunology
  • Leukocytes, Mononuclear / metabolism
  • Lymphocyte Activation
  • Lymphocyte Culture Test, Mixed
  • Molecular Sequence Data
  • Protein Structure, Secondary
  • Receptors, Interleukin-2 / immunology
  • Receptors, Interleukin-2 / metabolism*
  • T-Lymphocytes / immunology*
  • T-Lymphocytes, Cytotoxic / immunology

Substances

  • Interleukin-15
  • Interleukin-2
  • Interleukins
  • Receptors, Interleukin-2

Associated data

  • GENBANK/U03099
  • GENBANK/U14407