Abstract
A cytokine was identified that stimulated the proliferation of T lymphocytes, and a complementary DNA clone encoding this new T cell growth factor was isolated. The cytokine, designated interleukin-15 (IL-15), is produced by a wide variety of cells and tissues and shares many biological properties with IL-2. Monoclonal antibodies to the beta chain of the IL-2 receptor inhibited the biological activity of IL-15, and IL-15 competed for binding with IL-2, indicating that IL-15 uses components of the IL-2 receptor.
MeSH terms
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Amino Acid Sequence
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Animals
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Cells, Cultured
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Cloning, Molecular*
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Haplorhini
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Humans
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Interleukin-15
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Interleukin-2 / immunology
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Interleukin-2 / metabolism
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Interleukin-2 / pharmacology
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Interleukins / chemistry
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Interleukins / genetics*
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Interleukins / metabolism
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Interleukins / pharmacology
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Killer Cells, Lymphokine-Activated / immunology
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Leukocytes, Mononuclear / immunology
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Leukocytes, Mononuclear / metabolism
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Lymphocyte Activation
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Lymphocyte Culture Test, Mixed
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Molecular Sequence Data
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Protein Structure, Secondary
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Receptors, Interleukin-2 / immunology
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Receptors, Interleukin-2 / metabolism*
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T-Lymphocytes / immunology*
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T-Lymphocytes, Cytotoxic / immunology
Substances
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Interleukin-15
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Interleukin-2
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Interleukins
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Receptors, Interleukin-2
Associated data
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GENBANK/U03099
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GENBANK/U14407