Cloning of two novel ABC transporters mapping on human chromosome 9

Genomics. 1994 May 1;21(1):150-9. doi: 10.1006/geno.1994.1237.

Abstract

The family of ATP binding cassette (ABC) transporters or traffic ATPases is composed of several membrane-associated proteins that transport a great variety of solutes across cellular membranes. Two novel mammalian members of the family, ABC1 and ABC2, have been identified by a PCR-based approach. They belong to a group of traffic ATPases encoded as a single multifunctional protein, such as CFTR, STE 6, and P-glycoproteins. Their peculiar structural features and close relationship to ABC transporters involved in nodulation suggest that ABC1 and ABC2 define a novel subgroup of mammalian traffic ATPases.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • ATP Binding Cassette Transporter 1
  • ATP-Binding Cassette Transporters / classification
  • ATP-Binding Cassette Transporters / genetics*
  • Adenosine Triphosphatases / classification
  • Adenosine Triphosphatases / genetics*
  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Biological Transport, Active
  • Chromosome Mapping
  • Chromosomes, Human, Pair 9*
  • Cloning, Molecular
  • Cricetinae
  • DNA, Complementary / genetics
  • Gene Expression
  • Genes
  • Humans
  • Membrane Proteins / genetics*
  • Molecular Sequence Data
  • Multigene Family*
  • Polymerase Chain Reaction
  • Sequence Alignment
  • Sequence Homology, Amino Acid
  • Tumor Cells, Cultured

Substances

  • ABCA1 protein, human
  • ATP Binding Cassette Transporter 1
  • ATP-Binding Cassette Transporters
  • DNA, Complementary
  • Membrane Proteins
  • Adenosine Triphosphatases

Associated data

  • GENBANK/X75926
  • GENBANK/X75927
  • SWISSPROT/P06795
  • SWISSPROT/P08716
  • SWISSPROT/P21440
  • SWISSPROT/P21958
  • SWISSPROT/P23361
  • SWISSPROT/P23703