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Three residues in the common beta chain of the human GM-CSF, IL-3 and IL-5 receptors are essential for GM-CSF and IL-5 but not IL-3 high affinity binding and interact with Glu21 of GM-CSF.
EMBO J. 1994 Nov 1;13(21):5176-85. doi: 10.1002/j.1460-2075.1994.tb06848.x.
EMBO J. 1994.
PMID: 7957082
Free PMC article.
Human interleukin-3 (IL-3) induces disulfide-linked IL-3 receptor alpha- and beta-chain heterodimerization, which is required for receptor activation but not high-affinity binding.
Stomski FC, Sun Q, Bagley CJ, Woodcock J, Goodall G, Andrews RK, Berndt MC, Lopez AF.
Stomski FC, et al.
Mol Cell Biol. 1996 Jun;16(6):3035-46. doi: 10.1128/MCB.16.6.3035.
Mol Cell Biol. 1996.
PMID: 8649415
Free PMC article.
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