Abstract
The genomic structure of Stat2 has been determined and compared with a large portion of the Stat1 gene. There are 24 exons in the Stat2 gene and a matching number in very similar positions in the Stat1 gene. Thus a very complicated genomic structure was presumably duplicated and has been closely maintained throughout evolution.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Alternative Splicing
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Amino Acid Sequence
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Base Sequence
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Cloning, Molecular
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Conserved Sequence / genetics
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DNA-Binding Proteins / genetics*
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DNA-Binding Proteins / metabolism
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Exons / genetics*
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Gene Expression Regulation / drug effects
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HeLa Cells
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Humans
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Interferon-Stimulated Gene Factor 3
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Interferon-Stimulated Gene Factor 3, gamma Subunit
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Interferon-alpha / pharmacology
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Molecular Sequence Data
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Promoter Regions, Genetic / genetics
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Recombinant Fusion Proteins / biosynthesis
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Restriction Mapping
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STAT1 Transcription Factor
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STAT2 Transcription Factor
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Sequence Analysis, DNA
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Sequence Deletion / physiology
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Trans-Activators / genetics*
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Transcription Factors / metabolism
Substances
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DNA-Binding Proteins
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IRF9 protein, human
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Interferon-Stimulated Gene Factor 3
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Interferon-Stimulated Gene Factor 3, gamma Subunit
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Interferon-alpha
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Recombinant Fusion Proteins
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STAT1 Transcription Factor
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STAT1 protein, human
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STAT2 Transcription Factor
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STAT2 protein, human
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Trans-Activators
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Transcription Factors
Associated data
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GENBANK/U18662
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GENBANK/U18663
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GENBANK/U18664
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GENBANK/U18665
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GENBANK/U18666
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GENBANK/U18667
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GENBANK/U18668
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GENBANK/U18669
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GENBANK/U18670
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GENBANK/U18671