Abstract
Four human protein-tyrosine phosphatase (PTPase) genes of the VH1-like subclass were cloned by low-stringency screening of a genomic library. These genes were localized to their respective chromosomes by G-banding and fluorescence in situ hybridization. The genes were localized to unique regions of different chromosomes: CL100, a stress-induced PTPase, to 5q35; PAC-1, a mitogen-induced nuclear PTPase, to 2q11;hVH-3 to 10q25; and hVH-4 to 10q11.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Chromosome Mapping
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Chromosomes, Human, Pair 10*
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Chromosomes, Human, Pair 2*
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Chromosomes, Human, Pair 5*
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Dual-Specificity Phosphatases
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Humans
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In Situ Hybridization, Fluorescence
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Protein Tyrosine Phosphatases / chemistry*
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Protein Tyrosine Phosphatases / genetics*
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Sequence Alignment
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Sequence Homology, Amino Acid
Substances
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dual specificity phosphatase 12
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Dual-Specificity Phosphatases
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Protein Tyrosine Phosphatases