Chromosomal localization of four human VH1-like protein-tyrosine phosphatases

Genomics. 1994 Jul 15;22(2):462-4. doi: 10.1006/geno.1994.1411.

Abstract

Four human protein-tyrosine phosphatase (PTPase) genes of the VH1-like subclass were cloned by low-stringency screening of a genomic library. These genes were localized to their respective chromosomes by G-banding and fluorescence in situ hybridization. The genes were localized to unique regions of different chromosomes: CL100, a stress-induced PTPase, to 5q35; PAC-1, a mitogen-induced nuclear PTPase, to 2q11;hVH-3 to 10q25; and hVH-4 to 10q11.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Chromosome Mapping
  • Chromosomes, Human, Pair 10*
  • Chromosomes, Human, Pair 2*
  • Chromosomes, Human, Pair 5*
  • Dual-Specificity Phosphatases
  • Humans
  • In Situ Hybridization, Fluorescence
  • Protein Tyrosine Phosphatases / chemistry*
  • Protein Tyrosine Phosphatases / genetics*
  • Sequence Alignment
  • Sequence Homology, Amino Acid

Substances

  • dual specificity phosphatase 12
  • Dual-Specificity Phosphatases
  • Protein Tyrosine Phosphatases