PVT1 lncRNA in lung cancer: A key player in tumorigenesis and therapeutic opportunities

Mohammed Ageeli Hakami; Ali Hazazi; Farhan R Khan; Osama Abdulaziz; Khalid Alshaghdali; Adil Abalkhail; Somia A Nassar; Bashir Ibrahim A Omar; Fahad Almarshadi; Gaurav Gupta; Abdulkarim S Binshaya

doi:10.1016/j.prp.2023.155019

PVT1 lncRNA in lung cancer: A key player in tumorigenesis and therapeutic opportunities

Pathol Res Pract. 2024 Jan:253:155019. doi: 10.1016/j.prp.2023.155019. Epub 2023 Dec 7.

Affiliations

¹ Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Al-Quwayiyah, Shaqra university, Riyadh, Saudi Arabia.
² Department of Pathology and Laboratory Medicine, Security Forces Hospital Program, Riyadh, Saudi Arabia.
³ Clinical Laboratory Sciences Department, College of Applied Medical Sciences, Taif University, Makkah, Saudi Arabia.
⁴ Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, University of Hail, P.O Box 2440, Saudi Arabia.
⁵ Department of Public Health, College of Public Health and Health Informatics, Qassim University, Qassim, Saudi Arabia.
⁶ Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Alkharj 11942, Saudi Arabia; Department of Parasitology & Animal Diseases, National Research Centre, 33 Bohouth St., Dokki, Giza 12622, Egypt.
⁷ Department of Public Health, College of Public Health and Health Informatics, University of Ha'il, Saudi Arabia.
⁸ Centre for Global Health Research, Saveetha Medical College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, India; School of Pharmacy, Graphic Era Hill University, Dehradun 248007, India; School of Pharmacy, Suresh Gyan Vihar University, Mahal Road, Jagatpura, Jaipur, India.
⁹ Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Alkharj 11942, Saudi Arabia. Electronic address: abdulkarim.spharma@outlook.com.

PMID: 38091883
DOI: 10.1016/j.prp.2023.155019

Abstract

The lncRNA PVT1 has emerged as a pivotal component in the intricate landscape of cancer pathogenesis, particularly in lung cancer. PVT1, situated in the 8q24 chromosomal region, has garnered attention for its aberrant expression patterns in lung cancer, correlating with tumor progression, metastasis, and poor prognosis. Numerous studies have unveiled the diverse mechanisms PVT1 contributes to lung cancer pathogenesis. It modulates critical pathways, such as cell proliferation, apoptosis evasion, angiogenesis, and epithelial-mesenchymal transition. PVT1's interactions with other molecules, including microRNAs and proteins, amplify its oncogenic influence. Recent advancements in genomic and epigenetic analyses have also illuminated the intricate regulatory networks that govern PVT1 expression. Understanding PVT1's complex involvement in lung cancer holds substantial clinical implications. Targeting PVT1 presents a promising avenue for developing novel diagnostic biomarkers and therapeutic interventions. This abstract encapsulates the expanding knowledge regarding the oncogenic role of PVT1 in lung cancer, underscoring the significance of further research to unravel its complete mechanistic landscape and exploit its potential for improved patient outcomes.

Keywords: LncRNA PVT1; Lung cancer; Molecular mechanisms; Non-coding RNA; Oncogenic potential; Pathogenesis.

Publication types

Review

MeSH terms

Carcinogenesis / genetics
Cell Line, Tumor
Cell Proliferation / genetics
Cell Transformation, Neoplastic / genetics
Gene Expression Regulation, Neoplastic / genetics
Humans
Lung Neoplasms* / pathology
MicroRNAs* / genetics
RNA, Long Noncoding* / genetics
RNA, Long Noncoding* / metabolism

Substances

RNA, Long Noncoding
MicroRNAs