The Multifaceted Role of Annexin A1 in Viral Infections

Filipe Resende; Simone de Araújo; Luciana Pádua Tavares; Mauro Martins Teixeira; Vivian Vasconcelos Costa

doi:10.3390/cells12081131

The Multifaceted Role of Annexin A1 in Viral Infections

Cells. 2023 Apr 11;12(8):1131. doi: 10.3390/cells12081131.

Authors

Filipe Resende^{1

2}, Simone de Araújo², Luciana Pádua Tavares³, Mauro Martins Teixeira^{2

4}, Vivian Vasconcelos Costa^{1

2}

Affiliations

¹ Post-Graduation Program of Cell Biology, Department of Morphology, Biological Sciences Institute, Federal University of Minas Gerais, Belo Horizonte 31270-901, Brazil.
² Center for Research and Development of Drugs, Biological Sciences Institute, Federal University of Minas Gerais, Belo Horizonte 31270-901, Brazil.
³ Pulmonary and Critical Care Medicine Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
⁴ Department of Biochemistry and Immunology, Biological Sciences Institute, Federal University of Minas Gerais, Belo Horizonte 31270-901, Brazil.

Abstract

Dysregulated inflammatory responses are often correlated with disease severity during viral infections. Annexin A1 (AnxA1) is an endogenous pro-resolving protein that timely regulates inflammation by activating signaling pathways that culminate with the termination of response, clearance of pathogen and restoration of tissue homeostasis. Harnessing the pro-resolution actions of AnxA1 holds promise as a therapeutic strategy to control the severity of the clinical presentation of viral infections. In contrast, AnxA1 signaling might also be hijacked by viruses to promote pathogen survival and replication. Therefore, the role of AnxA1 during viral infections is complex and dynamic. In this review, we provide an in-depth view of the role of AnxA1 during viral infections, from pre-clinical to clinical studies. In addition, this review discusses the therapeutic potential for AnxA1 and AnxA1 mimetics in treating viral infections.

Keywords: Annexin A1; FPR2; host-directed therapies; infection; inflammation; virus.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Annexin A1* / metabolism
Humans
Inflammation / metabolism
Signal Transduction
Virus Diseases*

Substances

Annexin A1

Grants and funding

This work received financial support from the National Institute of Science and Technology in Dengue and Host-microorganism Interaction (INCT dengue), a program funded by The Brazilian National Science Council (CNPq, Brazil process 465425/2014-3) and Minas Gerais Foundation for Science (FAPEMIG, Brazil process 25036/2014-3) and from Rede de Pesquisa em Imunobiológicos e Biofármacos para terapias avançadas e inovadoras (ImunoBioFar), provided by FAPEMIG under process RED-00202-22” 29568-1. This study was also financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES, Brazil), process 88881.507175/2020-01. The authors also thank L’Oréal-UNESCO-ABC ‘Para Mulheres na Ciência’ prize granted to VVC, and the PhD scholarship provided by CAPES to F.R., under project process 88881.507175/2020-01.