Objective: To study the diagnostic value of lipoprotein-associated phospholipase A2(LP-PL-A2) in occult pancreaticobiliary reflux(OPBR) combined with gallbladder cholesterol deposition. Methods: This was a case-control study. Forty-six patients with OPBR who underwent gallbladder surgery at Shanghai East Hospital from December 2020 to October 2021, with gallbladder cholesterol deposition as the case group and the remainder as the control group, were included for analysis of their clinical data. Results: There were 21 cases in the case group, with 10 males and 11 females, and aged (57±12) years; 25 cases in the control group, with 11 males and 14 females, and aged (56±10) years. Serum LP-PL-A2 [(551.62±128.69) U/L] was significantly higher in the case group than in the control group [(436.70±135.88) U/L] (t=-2.80,P<0.01).Univariate analysis showed that LP-PL-A2 was a risk factor for OPBR combined with gallbladder cholesterol deposition, OR(95%CI):1.007(1.002-1.012), P=0.011. The area under the receiver operating characteristic curve (ROC) curve was 0.742, P=0.005. Conclusion: LP-PL-A2 is of diagnostic value in OPBR combined with gallbladder cholesterol deposition.
目的： 观察脂蛋白相关磷脂酶A2（LP-PL-A2）对隐匿性胰胆反流（OPBR）合并胆囊胆固醇沉积症的诊断价值。 方法： 本研究为病例对照研究。回顾性纳入2020年12月到2021年10月在同济大学附属东方医院中心行胆囊手术的46例OPBR患者，其中合并胆囊胆固醇沉积症的患者设为病例组，未合并者设为对照组，分析两组患者术前LP-PL-A2的水平，以受试者工作特征（ROC）曲线对OPBR合并胆囊胆固醇沉积症进行诊断及预测能力分析。 结果： 46例OPBR患者中，病例组21例，男10例，女11例，年龄（57±12）岁；对照组25例，男11例，女14例，年龄（56±10）岁；病例组血清LP-PL-A2显著高于对照组［（551.62±128.69）U/L比（436.70±135.88）U/L，t=-2.80，P<0.01］。单因素分析显示LP-PL-A2是OPBR合并胆囊胆固醇沉积症的相关因素，OR（95%CI）：1.007（1.002~1.012），P=0.011。ROC曲线显示曲线下面积为0.742，P=0.005。 结论： 血清中LP-PL-A2对诊断OPBR合并胆囊胆固醇沉积症有一定价值。.