[Case report of pulmonary embolism after balloon pulmonary angioplasty triggered by decreased antithrombin Ⅲ activity in a patient with chronic thromboembolic disease]

Zhonghua Xin Xue Guan Bing Za Zhi. 2023 Jan 24;51(1):76-79. doi: 10.3760/cma.j.cn112148-20221130-00950.
[Article in Chinese]

Abstract

球囊肺动脉成形术(BPA)在临床上广泛应用于肺动脉狭窄闭塞疾病,其有效性和安全性已得到证实,尤其在慢性血栓栓塞性肺动脉高压或慢性肺血栓栓塞性疾病(CTED)中。其最常见的并发症有肺损伤咯血和再灌注肺水肿等。抗凝治疗是血栓栓塞性疾病的基础治疗手段,可有效防止血栓再形成和复发。普通肝素是抗凝药物中的一种,经常在BPA中使用,若抗凝效果不佳,有可能导致严重的后果。该文报道1例抗凝血酶Ⅲ(AT-Ⅲ)活性下降的CTED患者,两次BPA术后发生肺栓塞。期望通过此病例加强术者对AT-Ⅲ的重视及对此类患者BPA术中处理的探讨,减少类似事件发生。.

Publication types

  • Case Reports

MeSH terms

  • Angioplasty, Balloon* / adverse effects
  • Antithrombin III* / genetics
  • Antithrombin III* / metabolism
  • Chronic Disease
  • Humans
  • Pulmonary Artery*
  • Pulmonary Embolism* / etiology
  • Thromboembolism* / genetics
  • Thromboembolism* / metabolism
  • Thromboembolism* / therapy

Substances

  • Antithrombin III