A review on the role of PRNCR1 in human disorders with an especial focus on cancer

Soudeh Ghafouri-Fard; Tayyebeh Khoshbakht; Bashdar Mahmud Hussen; Aria Baniahmad; Mohammad Taheri; Alireza Salimi

doi:10.1016/j.prp.2022.154026

A review on the role of PRNCR1 in human disorders with an especial focus on cancer

Pathol Res Pract. 2022 Sep:237:154026. doi: 10.1016/j.prp.2022.154026. Epub 2022 Jul 13.

Authors

Soudeh Ghafouri-Fard¹, Tayyebeh Khoshbakht², Bashdar Mahmud Hussen³, Aria Baniahmad⁴, Mohammad Taheri⁵, Alireza Salimi⁶

Affiliations

¹ Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran.
² Men's Health and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran.
³ Department of Pharmacognosy, College of Pharmacy, Hawler Medical University, Kurdistan Region, Erbil, Iraq; Center of Research and Strategic Studies, Lebanese French University, Erbil, Kurdistan Region, Iraq.
⁴ Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran.
⁵ Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran; Institute of Human Genetics, Jena University Hospital, Jena, Germany. Electronic address: mohammad.taheri@uni-jena.de.
⁶ Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran. Electronic address: arsalimi@sbmu.ac.ir.

PMID: 35849867
DOI: 10.1016/j.prp.2022.154026

Abstract

Prostate Cancer Associated Non-Coding RNA 1 (PRNCR1) is a long non-coding RNA (lncRNA) which is transcribed from chromosome 8, plus strand. This lncRNA has been reported to be an oncogenic transcript participating in the pathogenesis of several kinds of cancers. Some single nucleotide polymorphisms within this lncRNA affect cancer risk. Moreover, few studies have revealed its possible roles in some non-neoplastic conditions, such as cisplatin-induced acute kidney injury, osteolysis after hip replacement, preeclampsia and pulmonary disorders. In the present narrative review, we explain diverse roles of PRNCR1 in human disorders.

Keywords: Biomarker; Cancer; Expression; LncRNA; PRNCR1.

Publication types

Review

MeSH terms

Acute Kidney Injury / genetics
Cisplatin
Female
Humans
Neoplasms* / genetics
Osteolysis / genetics
Polymorphism, Single Nucleotide
Pre-Eclampsia / genetics
RNA, Long Noncoding* / genetics

Substances

Cisplatin
RNA, Long Noncoding
PRNCR1 long non-coding RNA, human