A close shave: How SARS-CoV-2 induces the loss of cilia

J Cell Biol. 2022 Jul 4;221(7):e202206023. doi: 10.1083/jcb.202206023. Epub 2022 Jun 13.

Abstract

Wang et al. report in this issue (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202108015) that the SARS-CoV-2 protein ORF10 increases the activity of the E3 ligase CUL2ZYG11B, leading to the degradation of multiple ciliary proteins. The resulting loss of cilia may facilitate the spread of SARS-CoV-2 in the respiratory tree.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • COVID-19* / pathology
  • Cell Cycle Proteins
  • Cilia* / pathology
  • Cullin Proteins
  • Genes, Viral
  • Humans
  • Proteins / metabolism
  • SARS-CoV-2
  • Ubiquitin-Protein Ligases* / metabolism

Substances

  • CUL2 protein, human
  • Cell Cycle Proteins
  • Cullin Proteins
  • Proteins
  • ZYG11A protein, human
  • Ubiquitin-Protein Ligases

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