The association between LIN28A gene rare variants and Parkinson's disease in Chinese population

Xiurong Huang; Yuwen Zhao; Hongxu Pan; Yige Wang; Zhenhua Liu; Qian Xu; Qiying Sun; Jieqiong Tan; Xinxiang Yan; Jinchen Li; Beisha Tang; Jifeng Guo

doi:10.1016/j.gene.2022.146515

The association between LIN28A gene rare variants and Parkinson's disease in Chinese population

Gene. 2022 Jun 30:829:146515. doi: 10.1016/j.gene.2022.146515. Epub 2022 Apr 18.

Authors

Xiurong Huang¹, Yuwen Zhao¹, Hongxu Pan¹, Yige Wang¹, Zhenhua Liu¹, Qian Xu¹, Qiying Sun², Jieqiong Tan³, Xinxiang Yan¹, Jinchen Li⁴, Beisha Tang⁵, Jifeng Guo⁶

Affiliations

¹ Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
² Department of Geriatrics, Xiangya Hospital, Central South University, Changsha, Hunan, China.
³ Centre for Medical Genetics & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China.
⁴ National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China; Centre for Medical Genetics & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China; Department of Geriatrics, Xiangya Hospital, Central South University, Changsha, Hunan, China.
⁵ Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China; Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, Hunan, China; Centre for Medical Genetics & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China.
⁶ Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China; Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, Hunan, China; Centre for Medical Genetics & Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China; Hunan International Scientific and Technological Cooperation Base of Neurodegenerative and Neurogenetic Diseases, Changsha, China. Electronic address: guojifeng2003@163.com.

PMID: 35447238
DOI: 10.1016/j.gene.2022.146515

Abstract

Parkinson's disease (PD) is a neurodegenerative disease caused by aging, environmental and genetic factors, and many susceptibility genes have been found to increase the risk for PD. Lin28a, an RNA binding protein, is expressed prominently in neural progenitor cells. The expression of Lin28a is decreased gradually with neural differentiation and is implicated in oncogenesis, glucose metabolism, neurogenesis, and neurogliogenesis. However, few genetic studies have explored the association between rare variants of the LIN28A gene and PD yet. Our study recruited 3,879 PD patients and 2,931 controls, and they were divided into two cohorts, including the EOPD & FPD cohort and the LOPD cohort, separately sequenced by whole-exome sequencing and whole-genome sequencing. We found nine rare nonsynonymous variants in the coding region of the LIN28A gene, but the rare variants of this gene were not enriched in PD patients in both cohorts. Thence, our study did not support the association between the LIN28A gene and the PD risk in the Chinese mainland population.

Keywords: LIN28A gene; Neurogenesis; Parkinson’s disease; Rare nonsynonymous variants.

MeSH terms

Age of Onset
Asian People
China
Genetic Predisposition to Disease
Humans
Parkinson Disease* / genetics
RNA-Binding Proteins / genetics

Substances

Lin28A protein, human
RNA-Binding Proteins