LINC00520: A Potential Diagnostic and Prognostic Biomarker in Cancer

Qiudan Zhang; Jinze Shen; Yuchen Wu; Wenjing Ruan; Feng Zhu; Shiwei Duan

doi:10.3389/fimmu.2022.845418

LINC00520: A Potential Diagnostic and Prognostic Biomarker in Cancer

Front Immunol. 2022 Mar 2:13:845418. doi: 10.3389/fimmu.2022.845418. eCollection 2022.

Authors

Qiudan Zhang^{1

2}, Jinze Shen¹, Yuchen Wu³, Wenjing Ruan⁴, Feng Zhu¹, Shiwei Duan^{1

2}

Affiliations

¹ School of Medicine, Zhejiang University City College, Hangzhou, China.
² Medical Genetics Center, School of Medicine, Ningbo University, Ningbo, China.
³ Department of Clinical Medicine, The First School of Medicine, Wenzhou Medical University, Wenzhou, China.
⁴ Department of Respiratory Diseases, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

Abstract

Long non-coding RNA (lncRNA) is important in the study of cancer mechanisms. LINC00520 is located on human chromosome 14q22.3 and is a highly conserved long non-coding RNA. LINC00520 is widely expressed in various tissues. The expression of LINC00520 is regulated by transcription factors such as Sp1, TFAP4, and STAT3. The high expression of LINC00520 is significantly related to the risk of 11 cancers. LINC00520 can competitively bind 10 miRNAs to promote tumor cell proliferation, invasion, and migration. In addition, LINC00520 is involved in the regulation of P13K/AKT and JAK/STAT signaling pathways. The expression of LINC00520 is significantly related to the clinicopathological characteristics and prognosis of tumor patients and is also related to the sensitivity of HNSCC to radiotherapy. Here, this article summarizes the abnormal expression pattern of LINC00520 in cancer and its potential molecular regulation mechanism and points out that LINC00520 can be used as a potential biomarker for cancer diagnosis, prognosis, and treatment.

Keywords: JAK/STAT; LINC00520; P13K/AKT; ceRNA; prognosis; transcription factor.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Gene Expression Regulation, Neoplastic
Head and Neck Neoplasms* / genetics
Humans
Prognosis
RNA, Long Noncoding* / genetics
Squamous Cell Carcinoma of Head and Neck* / genetics

Substances

RNA, Long Noncoding