Association between serum netrin-1, netrin-4 and risk of the acute coronary syndrome in patients with type 2 diabetes mellitus-A pilot study

Kumar Inderjeet; Prashant Shankarrao Adole; K V Vinod; Ajith Ananthakrishna Pillai

doi:10.1016/j.ihj.2021.11.186

Association between serum netrin-1, netrin-4 and risk of the acute coronary syndrome in patients with type 2 diabetes mellitus-A pilot study

Indian Heart J. 2022 Jan-Feb;74(1):72-75. doi: 10.1016/j.ihj.2021.11.186. Epub 2021 Dec 4.

Authors

Kumar Inderjeet¹, Prashant Shankarrao Adole², K V Vinod³, Ajith Ananthakrishna Pillai⁴

Affiliations

¹ Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India.
² Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India. Electronic address: prashant.s@jipmer.edu.in.
³ Department of Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India.
⁴ Department of Cardiology, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India.

Abstract

The present study was done to assess the diagnostic utility of serum netrin-1 and netrin-4 for recognising the acute coronary syndrome (ACS) in type 2 diabetes mellitus (T2DM) patients. Forty-two T2DM patients with ACS (Cases) and forty-two T2DM patients without ACS (Controls) were compared. Cases had lower serum netrin-1 and netrin-4 levels than controls and were negatively associated with creatinine kinase-total, creatinine kinase-MB, troponin-T and H-FABP. ROC analysis showed that netrin-1 and netrin-4 had good sensitivity and specificity for ACS prediction in T2DM patients. Serum netrin-1 and netrin-4 levels might be considered complementary markers for ACS diagnosis in T2DM patients.

Keywords: Acute coronary syndrome; Netrin-1; Netrin-4; Type 2 diabetes mellitus.

MeSH terms

Acute Coronary Syndrome*
Biomarkers
Diabetes Mellitus, Type 2* / complications
Diabetes Mellitus, Type 2* / diagnosis
Humans
Netrin-1
Pilot Projects
ROC Curve

Substances

Biomarkers
NTN1 protein, human
Netrin-1