Impact of VSIG4 gene polymorphisms on susceptibility and functional status of rheumatoid arthritis

Fabiana Antunes Andrade; Isabela Goeldner Eibofner; Cristhine Pieczarka; Hoang van Tong; Leia Sena; Thelma Skare; Shirley Ramos da Rosa Utiyama; Iara Jose de Messias-Reason; Thirumalaisamy P Velavan

doi:10.1111/iji.12533

Impact of VSIG4 gene polymorphisms on susceptibility and functional status of rheumatoid arthritis

Int J Immunogenet. 2021 Jun;48(3):260-265. doi: 10.1111/iji.12533. Epub 2021 Mar 1.

Authors

Affiliations

¹ Laboratory of Molecular Immunopathology, Clinic Hospital, Federal University of Paraná, Curitiba, Brazil.
² Department of Medicine, Positive University, Curitiba, Brazil.
³ Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany.
⁴ Vietnamese-German Center for Medical Research, Hanoi, Vietnam.
⁵ Rheumatology Unit, Evangelical Hospital, Curitiba, Brazil.
⁶ Fondation Congolaise pour la Recherche Médicale, Brazzaville, Republic of Congo.
⁷ Duy Tan University, Da Nang, Vietnam.

PMID: 33645007
DOI: 10.1111/iji.12533

Abstract

The complement receptor of the immunoglobulin superfamily (CRIg, encoded by the VSIG4 gene) is a macrophage receptor involved in the clearance of immune complexes and autologous cells. Our results suggest that the VSIG4 rs1044165T allele is a risk factor for severe functional status of rheumatoid arthritis in women, possibly by affecting VSIG4 gene expression.

Keywords: DNA; arthritis; autoimmune; complement; disease; gene - polymorphism; immunology; molecular biology.

MeSH terms

Adolescent
Adult
Aged
Alleles
Arthritis, Rheumatoid / epidemiology
Arthritis, Rheumatoid / genetics*
Arthritis, Rheumatoid / pathology
Brazil / epidemiology
Genetic Association Studies*
Genetic Predisposition to Disease*
Humans
Middle Aged
Polymorphism, Single Nucleotide / genetics
Receptors, Complement / genetics*
Young Adult

Substances

Receptors, Complement
VSIG4 protein, human