Perforin gene variant A91V in young patients with severe COVID-19

Haematologica. 2020 Dec 1;105(12):2844-2846. doi: 10.3324/haematol.2020.260307.
No abstract available

Publication types

  • Case Reports

MeSH terms

  • COVID-19 / genetics
  • COVID-19 / immunology*
  • COVID-19 / virology
  • Cytotoxicity, Immunologic / immunology*
  • Female
  • Humans
  • Lymphohistiocytosis, Hemophagocytic / genetics
  • Lymphohistiocytosis, Hemophagocytic / immunology*
  • Lymphohistiocytosis, Hemophagocytic / virology
  • Male
  • Middle Aged
  • Mutation*
  • Perforin / genetics*
  • Prognosis
  • SARS-CoV-2 / immunology*
  • Severity of Illness Index

Substances

  • PRF1 protein, human
  • Perforin

Grants and funding

Funding: this work was supported by FIS-Instituto de Salud Carlos III, Grant Number: COV20/00181. This study was approved by the Institutional Ethical Board (20/167).