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Moyamoya disease patient mutations in the RING domain of RNF213 reduce its ubiquitin ligase activity and enhance NFκB activation and apoptosis in an AAA+ domain-dependent manner.
Biochem Biophys Res Commun. 2020 May 7;525(3):668-674. doi: 10.1016/j.bbrc.2020.02.024. Epub 2020 Mar 3.
Biochem Biophys Res Commun. 2020.
PMID: 32139119
Free article.
UBC13 is an RNF213-associated E2 ubiquitin-conjugating enzyme, and Lysine 63-linked ubiquitination by the RNF213-UBC13 axis is responsible for angiogenic activity.
Habu T, Harada KH.
Habu T, et al.
FASEB Bioadv. 2021 Jan 20;3(4):243-258. doi: 10.1096/fba.2019-00092. eCollection 2021 Apr.
FASEB Bioadv. 2021.
PMID: 33842849
Free PMC article.
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