Association Between BAK1 Gene rs210138 Polymorphisms and Testicular Germ Cell Tumors: A Systematic Review and Meta-Analysis

Front Endocrinol (Lausanne). 2020 Jan 23:11:2. doi: 10.3389/fendo.2020.00002. eCollection 2020.

Abstract

Background: Several studies including some genome-wide association studies (GWAS) had shown that BAK1 gene rs210138 polymorphisms might be associated with testicular germ cell tumors (TGCT). Here we tried to sum up the association through a systematic review and meta-analysis. Methods: Studies associated with BAK1 rs210138 and TGCT was systematically searched in databases. The effect size was pooled according to ORs and 95% CIs. Results: Our systematic review and meta-analysis comprised 14 articles. Significantly increased risk of TGCT was found in eligible GWAS and follow-up studies, in overall group and its Caucasian subgroup. Conclusions: Compared with adenine (A), BAK1 rs210138 guanine (G) is associated with increased risk of TGCT. Well-planned studies with larger sample size and more subgroups are needed to verify the risk identified in our systematic review and meta-analysis.

Keywords: BAK1; meta-analysis; rs210138; single nucleotide polymorphisms; testicular germ cell tumors.

Publication types

  • Meta-Analysis
  • Research Support, Non-U.S. Gov't
  • Systematic Review

MeSH terms

  • Case-Control Studies
  • Genetic Predisposition to Disease
  • Genome-Wide Association Study
  • Humans
  • Male
  • Neoplasms, Germ Cell and Embryonal / epidemiology
  • Neoplasms, Germ Cell and Embryonal / genetics*
  • Polymorphism, Single Nucleotide*
  • Testicular Neoplasms / epidemiology
  • Testicular Neoplasms / genetics*
  • bcl-2 Homologous Antagonist-Killer Protein / genetics*

Substances

  • BAK1 protein, human
  • bcl-2 Homologous Antagonist-Killer Protein

Supplementary concepts

  • Testicular Germ Cell Tumor