DGCR2 influences cortical thickness through a mechanism independent of schizophrenia pathogenesis

Sintia Iole Belangero; Vanessa Kiyomi Ota; Ary Gadelha; Arthur Almeida Berberian; Idaiane Batista de Assunção-Leme; Cristiano Noto; Denise Maria Christofolini; Fernanda Teixeira Bellucco; Marcos Leite Santoro; Diego Robles Mazzotti; André Zugman; Maria Isabel Melaragno; Marilia Arruda Cardoso Smith; Renata Pellegrino; Hakon Hakonarson; Quirino Cordeiro; Patricia Natalia Moretti; Rodrigo Affonseca Bressan; Jair de Jesus Mari; Andrea Parolin Jackowski

doi:10.1016/j.psychres.2019.02.068

DGCR2 influences cortical thickness through a mechanism independent of schizophrenia pathogenesis

Psychiatry Res. 2019 Apr:274:391-394. doi: 10.1016/j.psychres.2019.02.068. Epub 2019 Feb 27.

Authors

Sintia Iole Belangero¹, Vanessa Kiyomi Ota², Ary Gadelha³, Arthur Almeida Berberian³, Idaiane Batista de Assunção-Leme³, Cristiano Noto³, Denise Maria Christofolini⁴, Fernanda Teixeira Bellucco², Marcos Leite Santoro⁵, Diego Robles Mazzotti⁶, André Zugman³, Maria Isabel Melaragno², Marilia Arruda Cardoso Smith², Renata Pellegrino⁷, Hakon Hakonarson⁷, Quirino Cordeiro⁸, Patricia Natalia Moretti⁹, Rodrigo Affonseca Bressan³, Jair de Jesus Mari¹⁰, Andrea Parolin Jackowski³

Affiliations

¹ Disciplina de Genética, Departamento de Morfologia e Genética, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil; Laboratório Interdisciplinar de Neurociências Clínicas (LiNC), Departamento de Psiquiatria, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil. Electronic address: sinbelangero@gmail.com.
² Disciplina de Genética, Departamento de Morfologia e Genética, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil.
³ Laboratório Interdisciplinar de Neurociências Clínicas (LiNC), Departamento de Psiquiatria, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil; Departamento de Psiquiatria, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil.
⁴ Disciplina de Genética, Departamento de Morfologia e Genética, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil; Department of Collective Health, Faculdade de Medicina do ABC, Human Reproduction and Genetic Center, Santo André, Brazil.
⁵ Disciplina de Genética, Departamento de Morfologia e Genética, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil; Laboratório Interdisciplinar de Neurociências Clínicas (LiNC), Departamento de Psiquiatria, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil; Departamento de Psiquiatria, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil.
⁶ Center for Sleep and Circadian Neurobiology, University of Pennsylvania, Philadelphia, PA, United States.
⁷ Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, United States.
⁸ Departamento de Psiquiatria, Santa Casa School of Medical Sciences, São Paulo, Brazil.
⁹ Disciplina de Genética, Departamento de Morfologia e Genética, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil; Faculdade de Medicina, Universidade de Brasília (UNB), Brasília, Brazil.
¹⁰ Departamento de Psiquiatria, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil.

PMID: 30901624
DOI: 10.1016/j.psychres.2019.02.068

Abstract

We investigated the role of DGCR2, a corticogenesis-related gene, on schizophrenia (SZ) and its subphenotypes, including brain morphology. A total of 221 SZ patients, 263 controls and 70 antipsychotic-naïve first episode of psychosis (FEP) were genotyped for 17 DGCR2 polymorphisms. While no association between DGCR2 polymorphisms and SZ was found, the missense variant rs2072123 was associated to left rostral anterior cingulate thickness, showing that DGCR2 seems not to be associated directly with the SZ but might be influencing the brain morphology. We also showed a DGCR2 downregulation in SZ patients when compared to controls and FEP.

Keywords: DGCR2; Neuroimaging; Schizophrenia.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Female
Genotype
Gyrus Cinguli / pathology*
Humans
Male
Mutation, Missense
Platelet Glycoprotein GPIb-IX Complex / genetics*
Psychotic Disorders / genetics
Psychotic Disorders / pathology
Schizophrenia / genetics*
Schizophrenia / pathology*

Substances

Platelet Glycoprotein GPIb-IX Complex
adhesion receptor