The combination of single nucleotide polymorphisms rs6720173 (ABCG5), rs3808607 (CYP7A1), and rs760241 (DHCR7) is associated with differing serum cholesterol responses to dairy consumption

Appl Physiol Nutr Metab. 2018 Oct;43(10):1090-1093. doi: 10.1139/apnm-2018-0085. Epub 2018 Jun 19.

Abstract

Existing evidence on the influence of genetic architecture on serum cholesterol responsiveness to dietary interventions focuses on individual single nucleotide polymorphisms and single nutrients. We associated the combination of ABCG5 rs6720173-C, CYP7A1 rs3808607-TT, and DHCR7 rs760241-GG genotypes with lower low-density lipoprotein cholesterol concentrations relative to the combination of rs6720173-GG, rs3808607-G, and rs760241-A genotypes (-0.37 ± 0.12 (n = 9) vs. +0.38 ± 0.14 mmol/L (n = 7), p = 0.0016) following a blended dairy (3 servings/day for 4 weeks) intervention.

Keywords: SNP combination; cholesterol; cholestérol; combinaison de SNP; dairy; nutrigenetics; nutrigénétique; produits laitiers.

Publication types

  • Comparative Study
  • Multicenter Study
  • Randomized Controlled Trial

MeSH terms

  • ATP Binding Cassette Transporter, Subfamily G, Member 5 / genetics*
  • Adolescent
  • Adult
  • Aged
  • Biomarkers / blood
  • Cholesterol 7-alpha-Hydroxylase / genetics*
  • Cholesterol, LDL / blood*
  • Cross-Over Studies
  • Dairy Products*
  • Female
  • Genotype
  • Humans
  • Lipoproteins / genetics*
  • Male
  • Manitoba
  • Middle Aged
  • Oxidoreductases Acting on CH-CH Group Donors / genetics*
  • Phenotype
  • Polymorphism, Single Nucleotide*
  • Quebec
  • Young Adult

Substances

  • ABCG5 protein, human
  • ATP Binding Cassette Transporter, Subfamily G, Member 5
  • Biomarkers
  • Cholesterol, LDL
  • Lipoproteins
  • CYP7A1 protein, human
  • Cholesterol 7-alpha-Hydroxylase
  • Oxidoreductases Acting on CH-CH Group Donors
  • 7-dehydrocholesterol reductase