Abstract
DNA damage induces chemical and structural changes in our chromatin-embedded genome. In a recent issue of Nature Communications, Grundy et al. (2016) identify a role for PARP3 in the repair of single-strand breaks and reveal that PARP3 mono-ADP-ribosylates nucleosomal histone H2B.
Copyright © 2016 Elsevier Inc. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
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Comment
MeSH terms
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Animals
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B-Lymphocytes / cytology
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B-Lymphocytes / metabolism
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Cell Cycle Proteins / genetics*
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Cell Cycle Proteins / metabolism
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Cell Line, Tumor
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Chickens
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Chromatin / chemistry*
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Chromatin / metabolism
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DNA / genetics*
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DNA / metabolism
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DNA Breaks, Single-Stranded
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DNA Repair*
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Gene Expression Regulation
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Histones / genetics*
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Histones / metabolism
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Humans
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Poly(ADP-ribose) Polymerases / genetics*
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Poly(ADP-ribose) Polymerases / metabolism
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Xenopus laevis
Substances
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Cell Cycle Proteins
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Chromatin
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Histones
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DNA
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PARP3 protein, human
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Poly(ADP-ribose) Polymerases