Nick Your DNA, Mark Your Chromatin

Mol Cell. 2016 Oct 6;64(1):7-9. doi: 10.1016/j.molcel.2016.09.023.

Abstract

DNA damage induces chemical and structural changes in our chromatin-embedded genome. In a recent issue of Nature Communications, Grundy et al. (2016) identify a role for PARP3 in the repair of single-strand breaks and reveal that PARP3 mono-ADP-ribosylates nucleosomal histone H2B.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Animals
  • B-Lymphocytes / cytology
  • B-Lymphocytes / metabolism
  • Cell Cycle Proteins / genetics*
  • Cell Cycle Proteins / metabolism
  • Cell Line, Tumor
  • Chickens
  • Chromatin / chemistry*
  • Chromatin / metabolism
  • DNA / genetics*
  • DNA / metabolism
  • DNA Breaks, Single-Stranded
  • DNA Repair*
  • Gene Expression Regulation
  • Histones / genetics*
  • Histones / metabolism
  • Humans
  • Poly(ADP-ribose) Polymerases / genetics*
  • Poly(ADP-ribose) Polymerases / metabolism
  • Xenopus laevis

Substances

  • Cell Cycle Proteins
  • Chromatin
  • Histones
  • DNA
  • PARP3 protein, human
  • Poly(ADP-ribose) Polymerases