IFR4/MUM1-positive lymphoma in Waldeyer ring with co-expression of CD5 and CD10

Pediatr Blood Cancer. 2017 Feb;64(2):311-314. doi: 10.1002/pbc.26236. Epub 2016 Sep 12.

Abstract

IRF4/MUM1-positive lymphoma is a new subgroup of germinal center-derived B-cell lymphoma, predominantly involving the Waldeyer ring (WR) in children. CD5 expression is rare in these lymphomas. We report a 7-year-old Chinese male with B-cell lymphoma. Evaluation of his specimen by morphology, immunohistochemistry, and FISH analysis demonstrated IRF4/MUM1-positive lymphoma with strong and extensive CD5 and CD10 positivity. Despite the lack of t(14;18)(q32;q21) rearrangement, BCL2 protein was expressed. Our report highlights the clinicopathologic features of IFR4/MUM1-positive lymphoma in WR with co-expression of CD5 and CD10, and thereby provides insight into this newly recognized disease entity.

Keywords: CD5; IRF4/MUM1-positive lymphoma; Waldeyer ring; pediatric follicular lymphoma.

Publication types

  • Case Reports

MeSH terms

  • CD5 Antigens / genetics
  • CD5 Antigens / metabolism*
  • Child
  • Humans
  • Immunohistochemistry
  • In Situ Hybridization, Fluorescence
  • Interferon Regulatory Factors / genetics
  • Interferon Regulatory Factors / metabolism*
  • Lymphoma / classification
  • Lymphoma / metabolism
  • Lymphoma / pathology*
  • Male
  • Neprilysin / genetics
  • Neprilysin / metabolism*
  • Prognosis
  • Tonsillar Neoplasms / metabolism
  • Tonsillar Neoplasms / pathology*

Substances

  • CD5 Antigens
  • Interferon Regulatory Factors
  • interferon regulatory factor-4
  • Neprilysin