Abstract
Myeloid differentiation protein 2 (MD2) regulates bacterial lipopolysaccharide (LPS) triggered anti-bacterial immune response as a broker between LPS and Toll-like receptor 4 (TLR4). In this study, we identified a novel naturally occurring spliceosome of human MD2, termed as MD2-T3. This transcript lacked two exons of MD2 gene. By protein structure analysis and literature review, we predicted that MD2-T3 isoform might execute regulatory biological effects such as limiting LPS-triggered TLR4 signaling.
Keywords:
Lipopolysaccharide; Myeloid differentiation protein 2; Structure; Transcript.
Copyright © 2016 Elsevier B.V. All rights reserved.
MeSH terms
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Alternative Splicing*
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Amino Acid Sequence
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Base Sequence
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Cell Line
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Cloning, Molecular
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DNA, Complementary / genetics
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DNA, Complementary / immunology
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Escherichia coli / genetics
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Escherichia coli / metabolism
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HeLa Cells
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Humans
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Lipopolysaccharides / pharmacology
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Lymphocyte Antigen 96 / genetics*
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Lymphocyte Antigen 96 / immunology
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Monocytes / cytology
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Monocytes / drug effects
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Monocytes / immunology*
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Open Reading Frames
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Protein Isoforms / genetics
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Protein Isoforms / immunology
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Protein Structure, Secondary
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RNA, Messenger / genetics*
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RNA, Messenger / immunology
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Recombinant Proteins / genetics
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Recombinant Proteins / immunology
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Signal Transduction
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Spliceosomes / genetics
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Spliceosomes / immunology
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Toll-Like Receptor 4 / genetics
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Toll-Like Receptor 4 / immunology
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Transcription, Genetic*
Substances
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DNA, Complementary
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LY96 protein, human
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Lipopolysaccharides
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Lymphocyte Antigen 96
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Protein Isoforms
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RNA, Messenger
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Recombinant Proteins
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TLR4 protein, human
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Toll-Like Receptor 4