PIP4K2B: Coupling GTP Sensing to PtdIns5P Levels to Regulate Tumorigenesis

Trends Biochem Sci. 2016 Jun;41(6):473-475. doi: 10.1016/j.tibs.2016.04.003. Epub 2016 Apr 28.

Abstract

Although guanine nucleotides are essential for cell growth, how their levels are sensed in mammalian cells is unknown. Sumita et al. show that PIP4K2B, a phosphoinositide kinase, is a molecular sensor that transduces changes in GTP into changes in the levels of the phosphoinositide PtdIns5P to modulate tumour cell growth.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Adenosine Triphosphate / metabolism
  • Animals
  • Binding Sites
  • Cell Line, Transformed
  • Cell Proliferation
  • Cell Transformation, Neoplastic / genetics
  • Cell Transformation, Neoplastic / metabolism*
  • Cell Transformation, Neoplastic / pathology
  • Fibroblasts / metabolism
  • Fibroblasts / pathology
  • Gene Expression Regulation, Neoplastic*
  • Guanosine Triphosphate / metabolism*
  • Humans
  • Isoenzymes / genetics
  • Isoenzymes / metabolism
  • Kinetics
  • Mice
  • Mice, Nude
  • Mutation
  • Phosphatidylinositol Phosphates / metabolism*
  • Phosphotransferases (Alcohol Group Acceptor) / genetics*
  • Phosphotransferases (Alcohol Group Acceptor) / metabolism
  • Protein Binding
  • Signal Transduction

Substances

  • Isoenzymes
  • Phosphatidylinositol Phosphates
  • phosphatidylinositol 5-phosphate
  • Guanosine Triphosphate
  • Adenosine Triphosphate
  • Phosphotransferases (Alcohol Group Acceptor)
  • 1-phosphatidylinositol-4-phosphate 5-kinase