Abstract
Although guanine nucleotides are essential for cell growth, how their levels are sensed in mammalian cells is unknown. Sumita et al. show that PIP4K2B, a phosphoinositide kinase, is a molecular sensor that transduces changes in GTP into changes in the levels of the phosphoinositide PtdIns5P to modulate tumour cell growth.
Crown Copyright © 2016. Published by Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
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Comment
MeSH terms
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Adenosine Triphosphate / metabolism
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Animals
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Binding Sites
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Cell Line, Transformed
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Cell Proliferation
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Cell Transformation, Neoplastic / genetics
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Cell Transformation, Neoplastic / metabolism*
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Cell Transformation, Neoplastic / pathology
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Fibroblasts / metabolism
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Fibroblasts / pathology
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Gene Expression Regulation, Neoplastic*
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Guanosine Triphosphate / metabolism*
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Humans
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Isoenzymes / genetics
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Isoenzymes / metabolism
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Kinetics
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Mice
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Mice, Nude
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Mutation
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Phosphatidylinositol Phosphates / metabolism*
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Phosphotransferases (Alcohol Group Acceptor) / genetics*
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Phosphotransferases (Alcohol Group Acceptor) / metabolism
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Protein Binding
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Signal Transduction
Substances
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Isoenzymes
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Phosphatidylinositol Phosphates
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phosphatidylinositol 5-phosphate
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Guanosine Triphosphate
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Adenosine Triphosphate
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Phosphotransferases (Alcohol Group Acceptor)
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1-phosphatidylinositol-4-phosphate 5-kinase