Bioinformatic analysis of c-Myc target from laryngeal cancer cell gene of laryngeal cancer

J Cancer Res Ther. 2016 Jan-Mar;12(1):58-61. doi: 10.4103/0973-1482.146083.

Abstract

Aim of study: The aim was to explore the structure and functions of new target spot c-Myc target from laryngeal cancer cell. (MTLC) of c-Myc gene.

Methods: This study adopted bioinformatic methods to analyze the physicochemical property, secondary structure, hydrophobic region, a transmembrane region, and prediction of functions.

Results: The results showed that the whole length of the open reading frames was 708 bp, coding was 235 amino acids. This protein was a basic protein possessed two transmembrane structures and weight was about 26592.5 Da. The main elements of secondary structure were alpha-helix and random coil. MTLC was a membrane constitutive protein that possessed signal transduction and regulation may locate on karyotheca as results of subcellular localization and function prediction.

Conclusion: This study has provided the theoretical basis for the further discussion of the effect and mechanism of action of MTLC in the occurrence of laryngeal cancer.

MeSH terms

  • Computational Biology
  • Humans
  • Hydrophobic and Hydrophilic Interactions
  • Laryngeal Neoplasms / metabolism*
  • Laryngeal Neoplasms / pathology
  • Larynx / chemistry*
  • Larynx / metabolism
  • Larynx / pathology
  • Nuclear Proteins / chemistry*
  • Nuclear Proteins / metabolism
  • Protein Structure, Secondary
  • Proto-Oncogene Proteins c-myc / chemistry*
  • Proto-Oncogene Proteins c-myc / metabolism

Substances

  • MYC protein, human
  • MYCT1 protein, human
  • Nuclear Proteins
  • Proto-Oncogene Proteins c-myc