Context: Acute kidney injury (AKI) could lead to progressive chronic kidney disease (CKD).
Objectives: To demonstrate that urinary markers in AKI are associated with the degree of persistent renal injury.
Material and methods: Human L-FABP chromosomal transgenic (Tg) mice were subjected to ischemia-reperfusion (I/R) clamping renal pedicle for 20 min or 30 min. Kidneys were obtained at one and 40 days after I/R.
Results: Urinary L-FABP, NGAL, Kim-1 and albumin levels increased during the acute phase and were significantly correlated with the degree of tubulointerstitial fibrosis during the chronic phase.
Discussion and conclusion: These markers could detect higher risk of progression to CKD.
Keywords: AKI to CKD transition; Acute kidney injury; chronic kidney disease; renal damage.