NUDT15 c.415C>T increases risk of 6-mercaptopurine induced myelosuppression during maintenance therapy in children with acute lymphoblastic leukemia

Haematologica. 2016 Jan;101(1):e24-6. doi: 10.3324/haematol.2015.134775. Epub 2015 Sep 24.
No abstract available

Keywords: NUDT15; acute lymphoblastic leukemia; myelosuppression; pharmacogenetics.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Infant
  • Male
  • Mercaptopurine / administration & dosage*
  • Polymorphism, Genetic*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*
  • Pyrophosphatases / genetics*
  • Risk Factors

Substances

  • Mercaptopurine
  • NUDT15 protein, human
  • Pyrophosphatases