Oncostatin M and interleukin-31: Cytokines, receptors, signal transduction and physiology

Cytokine Growth Factor Rev. 2015 Oct;26(5):545-58. doi: 10.1016/j.cytogfr.2015.07.006. Epub 2015 Jul 3.

Abstract

Oncostatin M (OSM) and interleukin-31 (IL-31) are two cytokines belonging to the IL-6 family which share a common signaling receptor subunit, the OSM receptor beta (OSMRβ). Both of them are released by monocytes/macrophages, dendritic cells and T lymphocytes in inflammatory situations and upon binding to their respective receptor complexes they signal mainly via the JAK/STAT pathway. Besides sharing many biochemical properties, both display divergent physiological functions. This review summarizes aspects of cytokine transcription and biosynthesis, cytokine-receptor interactions, cross-species activities, signal transduction and physiology delineated from recent findings in genetic mouse models for both cytokines, OSM and IL-31.

Keywords: Cytokines; Inflammation; Interleukin-31; Oncostatin M; Signal transduction.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Humans
  • Interleukins / genetics
  • Interleukins / immunology*
  • Janus Kinases / genetics
  • Janus Kinases / immunology
  • Mice
  • Oncostatin M / genetics
  • Oncostatin M / immunology*
  • Oncostatin M Receptor beta Subunit / genetics
  • Oncostatin M Receptor beta Subunit / immunology*
  • STAT Transcription Factors / genetics
  • STAT Transcription Factors / immunology
  • Signal Transduction / genetics
  • Signal Transduction / immunology*

Substances

  • IL31 protein, human
  • Interleukins
  • OSM protein, human
  • OSMR protein, human
  • Oncostatin M Receptor beta Subunit
  • Osm protein, mouse
  • Osmr protein, mouse
  • STAT Transcription Factors
  • interleukin-31, mouse
  • Oncostatin M
  • Janus Kinases