Effects of miR-339-5p on invasion and prognosis of hepatocellular carcinoma

Clin Res Hepatol Gastroenterol. 2016 Feb;40(1):51-6. doi: 10.1016/j.clinre.2015.05.022. Epub 2015 Jul 15.

Abstract

microRNAs (miRNAs) are short single-strand non-coding RNAs that regulate various cell processes at the post-transcriptional levels. Mounting evidences suggested that dysregulation of miRNA is associated with cancer progression and development. The aberrant expression of miR-339-5p has been found in some types of cancers, however, the association of miR-339-5p expression and hepatocellular carcinoma (HCC) is still unclear. Here, we measured the expression of miR-339-5p in HCC tissues and explored its clinicopathological and prognostic significance. The result showed that miR-339-5p expression level was significantly lower in HCC tissues compared with non-cancerous liver tissues. Moreover, patients with lower miR-339-5p expression level are associated with a poorer overall survival. Multivariate Cox regression analysis showed that the expression of miR-339-5p was an independent prognostic factor for HCC patients. In addition, we found that over-expression of miR-339-5p can inhibit HCC cell invasion. In conclusion, our results indicated that miR-339-5p may serve as a tumor suppressor and play important role in inhibiting tumor invasion. Our work implicates that miR-339-5p may serve as a prognostic marker and molecular therapeutic target in HCC.

MeSH terms

  • Carcinoma, Hepatocellular / genetics*
  • Carcinoma, Hepatocellular / pathology*
  • Female
  • Humans
  • Liver Neoplasms / genetics*
  • Liver Neoplasms / pathology*
  • Male
  • MicroRNAs / physiology*
  • Middle Aged
  • Neoplasm Invasiveness
  • Prognosis

Substances

  • MIRN339 microRNA, human
  • MicroRNAs