Discoidin domain receptor-1 as a player in impairment of melanocytes adhesion process in vitiligo

G Ital Dermatol Venereol. 2016 Oct;151(5):473-9. Epub 2015 Jun 19.

Abstract

Background: The aim of this paper was to study immunohistochemical expression of discoidin domain receptor 1 (DDR1) in lesional and non-lesional skin of vitiligo patients in comparison to controls, to explore its possible implication vitiligo pathogenesis.

Methods: Twenty patients with non-segmental vitiligo (NSV) were subjected to punch biopsy from lesional and non-lesional vitiligo skin, in addition to punch biopsy from ten healthy subjects. All specimens were examined by H&E staining and by immunohistochemistry for DDR1 expression.

Results: Significantly decreased expression of DDR1 in lesional vitiligo skin in comparison to non-lesional skin was observed. In addition, decreased lesional and non-lesional DDR1 expression in vitiligo skin in comparison to controls was found.

Conclusions: Reduced DDR1 expression may be implicated in impaired melanocyte adhesion process involved in vitiligo pathogenesis.

MeSH terms

  • Adolescent
  • Adult
  • Biopsy / methods
  • Case-Control Studies
  • Cell Adhesion / genetics*
  • Discoidin Domain Receptor 1 / genetics*
  • Female
  • Humans
  • Immunohistochemistry
  • Male
  • Melanocytes / metabolism*
  • Middle Aged
  • Vitiligo / genetics
  • Vitiligo / pathology*
  • Young Adult

Substances

  • Discoidin Domain Receptor 1