Abstract
The pathogenesis of Cushing's disease is poorly understood; two recent reports identifying somatic mutations in USP8 in pituitary corticotroph tumors provide exciting advances in this field. These mutations alter EGFR trafficking and signaling, raising the prospect that EGFR inhibitors may move the treatment of this disease into the era of precision medicine.
MeSH terms
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ACTH-Secreting Pituitary Adenoma / drug therapy
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ACTH-Secreting Pituitary Adenoma / genetics
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ACTH-Secreting Pituitary Adenoma / pathology
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Endopeptidases / genetics
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Endosomal Sorting Complexes Required for Transport / genetics
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ErbB Receptors / antagonists & inhibitors
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ErbB Receptors / genetics
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Humans
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Mutation
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Pituitary ACTH Hypersecretion / drug therapy*
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Pituitary ACTH Hypersecretion / genetics*
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Pituitary ACTH Hypersecretion / pathology
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Precision Medicine*
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Signal Transduction / drug effects
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Ubiquitin Thiolesterase / genetics
Substances
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Endosomal Sorting Complexes Required for Transport
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ErbB Receptors
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Endopeptidases
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USP8 protein, human
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Ubiquitin Thiolesterase