Deregulated Levels of the NF-κB1, NF-κB2, and Rel Genes in Ukrainian Patients with Leukemia and Lymphoma in the Post-Chernobyl Period

Turk J Haematol. 2016 Mar 5;33(1):8-14. doi: 10.4274/tjh.2014.0190. Epub 2015 Apr 27.

Abstract

Objective: Nuclear factor kappa B (NF-κB) is an important transcription factor in cancer and NF-κB activation has been seen in angiogenesis, tumor progression, and metastasis. Relationships between specific NF-κB gene networks, leukemogenesis, and radiation exposure are still unknown. Our aim was to study the expression levels of the NF-κB1, NF-κB2, and Rel genes in hematological malignancies in the post-Chernobyl period.

Materials and methods: We analyzed gene expression levels of NF-κB1, NF-κB2, and Rel in 49 B-cell chronic lymphocytic leukemia, 8 B-cell non-Hodgkin's lymphoma, 3 acute myeloid leukemia, 3 chronic myeloid leukemia, 2 hairy cell leukemia, 2 myelodysplastic syndrome, and 2 T-cell large granular lymphocytic leukemia patients using real-time polymerase chain reaction.

Results: Expression levels of NF-κB1, NF-κB2, and Rel genes were found to be deregulated.

Conclusion: These results could be accepted as specific gene traces to radiation-induced leukemia or as potential candidates for new diagnostic biomarker studies. Larger experiments and non-exposed control malignant cell populations are needed to clarify these suggestions.

Amaç: Nükleer faktör kappa B (NF-κB), kanserde önemli bir transkripsiyon faktörü olup aktivasyonu anjiyogenez, tümör gelişimi ve metastazın birçok basamağında görülmektedir. Spesifik NF-κB gen ağları, lökomogenez ve radyasyon maruziyeti arasındaki ilişki halen belirsizdir. Çalışmamızda Çernobil sonrası hematolojik kanserlerde NF-κB1, NF-κB2 ve Rel genlerinin ekspresyon düzeylerini incelemeyi amaçladık. Gereç ve Yöntemler: Gerçek zamanlı polimeraz zincir reaksiyonu ile 49 B-hücreli kronik lenfositik lösemi, 8 B-hücreli non-Hodgkin lenfoma, 3 akut myeloid lösemi, 3 kronik myeloid lösemi, 2 tüylü hücre lösemi, 2 miyelodisplastik sendrom ve 2 T-hücreli büyük granüler lenfositik lösemi hastasında NF-κB1, NF-κB2 ve Rel gen ekspresyon düzeylerini analiz ettik. Bulgular: NF-κB1, NF-κB2 ve Rel genlerine ait ekspresyon düzeyleri değişmiş olarak saptandı. Sonuç: Bu sonuçlar, radyasyonla indüklenmiş lösemilerdeki spesifik gen izleri veya yeni tanısal biyobelirteç çalışmalarına muhtemel aday önerileri olarak da kabul edilebilir. Bu düşünceleri açıklığa kavuşturmak için daha geniş deneyler ve radyasyon maruziyeti olmayan kontrol malign hücre popülasyonlarına ihtiyaç vardır.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Chernobyl Nuclear Accident*
  • Female
  • Genes, rel*
  • Humans
  • Leukemia, Radiation-Induced / epidemiology
  • Leukemia, Radiation-Induced / etiology
  • Leukemia, Radiation-Induced / genetics*
  • Lymphoma / epidemiology
  • Lymphoma / etiology
  • Lymphoma / genetics*
  • Lymphoma / metabolism
  • Male
  • Middle Aged
  • Myelodysplastic Syndromes / epidemiology
  • Myelodysplastic Syndromes / etiology
  • Myelodysplastic Syndromes / genetics
  • Myelodysplastic Syndromes / metabolism
  • NF-kappa B / biosynthesis
  • NF-kappa B / genetics*
  • NF-kappa B p50 Subunit / biosynthesis
  • NF-kappa B p50 Subunit / genetics*
  • NF-kappa B p52 Subunit / biosynthesis
  • NF-kappa B p52 Subunit / genetics*
  • Neoplasms, Radiation-Induced / epidemiology
  • Neoplasms, Radiation-Induced / etiology
  • Neoplasms, Radiation-Induced / genetics*
  • Neoplasms, Radiation-Induced / metabolism
  • Real-Time Polymerase Chain Reaction
  • Transcription Factor RelA / biosynthesis
  • Transcription Factor RelA / genetics*
  • Ukraine / epidemiology
  • Young Adult

Substances

  • NF-kappa B
  • NF-kappa B p50 Subunit
  • NF-kappa B p52 Subunit
  • Transcription Factor RelA