Linkage between alpha 1B-glycoprotein (A1BG) and Lutheran (LU) red blood group system: assignment to chromosome 19: new genetic variants of A1BG

Clin Genet. 1989 Dec;36(6):415-8.

Abstract

alpha 1B-glycoprotein (A1BG) polymorphism was examined in a Danish family material (no. 604-1505) with particular regard to markers on chromosome 19. For A1BG-LU we found a lod score z = 3.06 at theta = 0.05 in males, and z = 1.42 at theta = 0.10 in females, which assigns A1BG to chromosome 19. Close linkage to C3, SE, PEPD, APOC2, D19S7, D19S8 and D19S9 was excluded. The most likely order would appear to be C3-SE-LU-A1BG.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Blood Proteins / genetics*
  • Chromosomes, Human, Pair 19*
  • Female
  • Gene Frequency / genetics
  • Genetic Linkage*
  • Genetic Variation / genetics
  • Glycoproteins*
  • Humans
  • Immunoglobulins*
  • Lod Score*
  • Lutheran Blood-Group System / genetics*
  • Male

Substances

  • A1BG protein, human
  • Blood Proteins
  • Glycoproteins
  • Immunoglobulins
  • Lutheran Blood-Group System