Role of SLCO1B1, ABCB1, and CHRNA1 gene polymorphisms on the efficacy of rocuronium in Chinese patients

Yang Mei; Sai-Ying Wang; Yang Li; Shuang-Qiang Yi; Chun-Yan Wang; Mi Yang; Kai-Ming Duan

doi:10.1002/jcph.405

Role of SLCO1B1, ABCB1, and CHRNA1 gene polymorphisms on the efficacy of rocuronium in Chinese patients

J Clin Pharmacol. 2015 Mar;55(3):261-8. doi: 10.1002/jcph.405. Epub 2014 Dec 22.

Authors

Yang Mei¹, Sai-Ying Wang^{1

2}, Yang Li¹, Shuang-Qiang Yi¹, Chun-Yan Wang¹, Mi Yang¹, Kai-Ming Duan¹

Affiliations

¹ Department of Anesthesiology, Third Xiangya Hospital of Central South University, Changsha, Hunan, People's Republic of China.
² Institute of Clinical Pharmacology, Central South University, Changsha, Hunan, People's Republic of China.

PMID: 25279974
DOI: 10.1002/jcph.405

Abstract

This study explored the role of SLCO1B1, ABCB1, and CHRNA1 gene polymorphisms on the efficacy and duration of action of rocuronium in Chinese patients. Two hundred seven unrelated Chinese patients scheduled for elective surgery were recruited, and 200 completed the study. Their ABCB1, SLCO1B1, and CHRNA1 genotypes were determined. Demographic and clinical non-genetic data also were collected. The SLCO1B1, ABCB1, and CHRNA1 variants did not affect the onset time of rocuronium. Clinical duration and recovery time of rocuronium were prolonged in patients with the ABCB1 rs1128503TT and SLCO1B1 rs2306283 AG and GG genotypes. We demonstrate that the SLCO1B1 and ABCB1 gene variants could affect the pharmacodynamics of rocuronium. The ABCB1 rs1128503 C>T genotype was the most important factor on the efficacy of rocuronium.

Keywords: ABCB1; CHRNA1; SLCO1B1; genetic polymorphism; pharmacogenetics.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

ATP Binding Cassette Transporter, Subfamily B / genetics
ATP Binding Cassette Transporter, Subfamily B / metabolism
Adult
Androstanols / pharmacokinetics
Androstanols / therapeutic use*
Asian People / genetics*
China
Elective Surgical Procedures
Female
Gene Frequency
Genotype
Humans
Liver-Specific Organic Anion Transporter 1 / genetics*
Liver-Specific Organic Anion Transporter 1 / metabolism
Male
Middle Aged
Muscle Relaxation / drug effects*
Neuromuscular Nondepolarizing Agents / pharmacokinetics
Neuromuscular Nondepolarizing Agents / therapeutic use*
Otorhinolaryngologic Surgical Procedures
Pharmacogenetics
Phenotype
Polymorphism, Single Nucleotide*
Receptors, Nicotinic / genetics*
Receptors, Nicotinic / metabolism
Rocuronium

Substances

ABCB1 protein, human
ATP Binding Cassette Transporter, Subfamily B
Androstanols
CHRNA1 protein, human
Liver-Specific Organic Anion Transporter 1
Neuromuscular Nondepolarizing Agents
Receptors, Nicotinic
SLCO1B1 protein, human
Rocuronium