Association of serum omentin-1 concentrations with the presence and severity of preeclampsia

Ann Clin Biochem. 2015 Mar;52(Pt 2):245-50. doi: 10.1177/0004563214541247. Epub 2014 Jun 9.

Abstract

Background: Inflammation is involved in the pathogenesis of preeclampsia. Omentin is a newly discovered adipokine that possesses an anti-inflammatory function. The aim of this study was to determine the association of serum omentin-1 concentration with the presence and severity of preeclampsia.

Methods: Serum concentrations of omentin-1 were measured in 128 women with preeclampsia and 96 women with uncomplicated pregnancies using an enzyme-linked immunosorbent assay method.

Results: Patients with preeclampsia had significantly lower serum concentrations of omentin-1 compared to healthy controls. In addition, those patients with severe preeclampsia had significantly lower concentrations of serum omentin-1 compared to those with mild preeclampsia. Simple linear regression analysis showed that in patients with preeclampsia the serum concentrations of omentin-1 showed significant correlation with body mass index (P < 0.001), systolic blood pressure (P < 0.05) and homeostasis model assessment of insulin resistance (P < 0.001).

Conclusion: Decreased concentrations of serum omentin-1 appear to be associated with the presence and severity of preeclampsia.

Keywords: Omentin-1; inflammation; preeclampsia.

MeSH terms

  • Adult
  • Biomarkers / blood
  • Blood Pressure
  • Body Mass Index
  • Case-Control Studies
  • Cytokines / blood*
  • Down-Regulation*
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • GPI-Linked Proteins / blood
  • Humans
  • Insulin Resistance
  • Lectins / blood*
  • Linear Models
  • Pre-Eclampsia / blood*
  • Pre-Eclampsia / metabolism
  • Pre-Eclampsia / physiopathology
  • Pregnancy
  • Severity of Illness Index

Substances

  • Biomarkers
  • Cytokines
  • GPI-Linked Proteins
  • ITLN1 protein, human
  • Lectins