Abstract
The functional role of brain G protein-coupled receptor 40 (GPR40) remains unclear. We investigated GPR40 signaling in depression-related behavior in mice via the forced swim test. A repeated but not a single intracerebroventricular administration of the GPR40 agonist, GW9508, reduced the duration of immobility behavior. Moreover, the levels of hippocampal non-esterified docosahexaenoic acid and arachidonic acid were decreased immediately after the forced swimming. These results suggested that brain GPR40 signaling may regulate depression-related behavior.
MeSH terms
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Animals
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Arachidonic Acid / metabolism
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Behavior, Animal
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Depression / genetics*
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Depression / metabolism
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Depression / psychology*
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Docosahexaenoic Acids / metabolism
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Hippocampus / metabolism
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Immobility Response, Tonic / drug effects
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Male
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Methylamines / pharmacology
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Mice
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Mice, Inbred Strains
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Propionates / pharmacology
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Receptors, G-Protein-Coupled / agonists
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Receptors, G-Protein-Coupled / physiology*
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Signal Transduction / genetics*
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Signal Transduction / physiology*
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Swimming / physiology
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Swimming / psychology
Substances
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Ffar1 protein, mouse
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GW9508
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Methylamines
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Propionates
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Receptors, G-Protein-Coupled
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Docosahexaenoic Acids
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Arachidonic Acid