Association between interleukin 10 gene polymorphisms and risk of type 2 diabetes mellitus in a Chinese population

J Int Med Res. 2014 Jun;42(3):702-10. doi: 10.1177/0300060513505813. Epub 2014 Apr 23.

Abstract

Objective: To investigate the relationship between the interleukin 10 (IL10) gene single nucleotide polymorphisms (SNP) -1082 G/A (rs1800896), -819 T/C (rs1800871) and -592 A/C (rs1800872) and risk of type 2 diabetes mellitus in a Chinese population.

Methods: This case-control study recruited patients with type 2 diabetes mellitus and healthy control subjects. Genotyping of the -1082 G/A (rs1800896), -819 T/C (rs1800871) and -592 A/C (rs1800872) SNPs was conducted and genotype frequencies were compared between the two groups.

Results: The study recruited 364 patients with type 2 diabetes mellitus and 677 healthy controls. Patients carrying the -1082 GG genotype had a significantly increased risk of type 2 diabetes mellitus (adjusted odds ratio [OR] 1.57, 95% confidence interval [CI] 1.03, 2.68), as did those patients carrying the -592 AA genotype (adjusted OR 1.63, 95% CI 1.06, 2.53). Subjects carrying both the -1082 GA + GG and -592 AC + AA genotypes had a significantly increased risk of type 2 diabetes mellitus (adjusted OR 2.03, 95% CI 1.24, 3.15).

Conclusions: The SNPs -1082G/A and -592 A/C increased the risk for type 2 diabetes mellitus, and could be potential targets for screening for the early detection of the risk of type 2 diabetes mellitus.

Keywords: IL10 gene; Interleukin 10; polymorphism; predictive markers; type 2 diabetes mellitus.

MeSH terms

  • 5' Untranslated Regions*
  • Adult
  • Aged
  • Asian People
  • Blood Glucose / metabolism
  • Case-Control Studies
  • Cholesterol, LDL / blood
  • Diabetes Mellitus, Type 2 / blood
  • Diabetes Mellitus, Type 2 / ethnology
  • Diabetes Mellitus, Type 2 / genetics*
  • Diabetes Mellitus, Type 2 / immunology
  • Female
  • Gene Expression
  • Genetic Predisposition to Disease*
  • Humans
  • Interleukin-10 / genetics*
  • Interleukin-10 / immunology
  • Male
  • Middle Aged
  • Odds Ratio
  • Polymorphism, Single Nucleotide*
  • Risk Factors
  • Sequence Analysis, DNA
  • Triglycerides / blood

Substances

  • 5' Untranslated Regions
  • Blood Glucose
  • Cholesterol, LDL
  • IL10 protein, human
  • Triglycerides
  • Interleukin-10