[Relationship between cystatin C and coronary artery calcification in patients with intermediate cardiovascular risk]

Med Clin (Barc). 2014 Dec 23;143(12):535-8. doi: 10.1016/j.medcli.2013.10.034. Epub 2014 Apr 13.
[Article in Spanish]

Abstract

Background and objective: Cardiovascular disease is the leading cause of morbimortality in industrialized countries. Quantification of coronary artery calcium (CAC) has been shown to have an independent and incremental prognostic value over traditional risk factors for the prediction of mortality and cardiovascular events. The aim of our study was to determine the possible relationship between CAC and cystatin C (CTC).

Patients and method: We included 104 patients with stable chest pain, free of cardiovascular disease and nephropathy, with intermediate cardiovascular risk. Both CAC (Agatston) and CTC were determined.

Results: CTC was independently associated with the CAC level and the presence of coronary disease.

Conclusions: CTC values may be associated with CAC and coronary disease. Further studies are needed to know the importance of these markers in clinical practice.

Keywords: Arterias coronarias; Aterosclerosis; Atherosclerosis; Cistatina C; Coronary arteries; Cystatin C.

Publication types

  • English Abstract
  • Observational Study

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Biomarkers / blood
  • Coronary Artery Disease / blood
  • Coronary Artery Disease / diagnosis*
  • Coronary Artery Disease / etiology
  • Cystatin C / blood*
  • Female
  • Humans
  • Logistic Models
  • Male
  • Middle Aged
  • Prognosis
  • Risk Factors
  • Vascular Calcification / blood
  • Vascular Calcification / complications
  • Vascular Calcification / diagnosis*

Substances

  • Biomarkers
  • Cystatin C